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OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 [ Homo sapiens (human) ]

Gene ID: 78990, updated on 7-Dec-2018

Summary

Official Symbol
OTUB2provided by HGNC
Official Full Name
OTU deubiquitinase, ubiquitin aldehyde binding 2provided by HGNC
Primary source
HGNC:HGNC:20351
See related
Ensembl:ENSG00000089723 MIM:608338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTB2; OTU2; C14orf137
Summary
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues See more
Orthologs

Genomic context

See OTUB2 in Genome Data Viewer
Location:
14q32.12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (94015600..94048930)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94489511..94515276)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984663 Neighboring gene coiled-coil domain containing 197 Neighboring gene DEAD-box helicase 24 Neighboring gene interferon alpha inducible protein 27 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
    Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3102, FLJ21916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NEDD8-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin thioesterase OTUB2
Names
OTU domain, ubiquitin aldehyde binding 2
OTU domain-containing ubiquitin aldehyde-binding protein 2
deubiquitinating enzyme OTUB2
otubain-2
ubiquitin-specific protease otubain 2
ubiquitin-specific-processing protease OTUB2
NP_075601.1
XP_005268112.1
XP_011535450.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023112.4NP_075601.1  ubiquitin thioesterase OTUB2

    See identical proteins and their annotated locations for NP_075601.1

    Status: VALIDATED

    Source sequence(s)
    AL079302
    Consensus CDS
    CCDS9917.1
    UniProtKB/Swiss-Prot
    Q96DC9
    Related
    ENSP00000203664.5, ENST00000203664.9
    Conserved Domains (1) summary
    pfam10275
    Location:1229
    Peptidase_C65; Peptidase C65 Otubain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    94015600..94048930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268055.4XP_005268112.1  ubiquitin thioesterase OTUB2 isoform X2

    See identical proteins and their annotated locations for XP_005268112.1

    Conserved Domains (1) summary
    pfam10275
    Location:2230
    Peptidase_C65; Peptidase C65 Otubain
  2. XM_011537148.3XP_011535450.1  ubiquitin thioesterase OTUB2 isoform X1

    See identical proteins and their annotated locations for XP_011535450.1

    Conserved Domains (1) summary
    pfam10275
    Location:20247
    Peptidase_C65; Peptidase C65 Otubain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    1140940..1163492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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