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Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 78975, updated on 4-Nov-2018

Summary

Official Symbol
Prkaa2provided by RGD
Official Full Name
protein kinase AMP-activated catalytic subunit alpha 2provided by RGD
Primary source
RGD:620893
See related
Ensembl:ENSRNOG00000007706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ampk; Ampka2
Summary
protein kinase that phosphorylates and inhibits acetyl-CoA carboxylase (ACC); rate-limiting enzyme in malonyl-CoA synthesis [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 915.1), Heart (RPKM 626.3) and 5 other tissues See more
Orthologs

Genomic context

See Prkaa2 in Genome Data Viewer
Location:
5q34
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (124568845..124642569, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (128436023..128503874, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene FYN binding protein 2 Neighboring gene metallothionein-2-like Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene phospholipid phosphatase 3 Neighboring gene uncharacterized LOC102549668

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
[acetyl-CoA carboxylase] kinase activity IEA
Inferred from Electronic Annotation
more info
 
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
energy homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tubulin deacetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-lysine acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of stress granule assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
 
response to activity IDA
Inferred from Direct Assay
more info
PubMed 
response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
Names
ACACA kinase
AMP-activated protein kinase
AMPK alpha-2 chain
AMPK subunit alpha-2
HMGCR kinase
acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_076481.1
XP_008762123.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023991.1NP_076481.1  5'-AMP-activated protein kinase catalytic subunit alpha-2

    See identical proteins and their annotated locations for NP_076481.1

    Status: PROVISIONAL

    Source sequence(s)
    Z29486
    UniProtKB/Swiss-Prot
    Q09137
    Related
    ENSRNOP00000010680.2, ENSRNOT00000010680.3
    Conserved Domains (4) summary
    cd12200
    Location:395550
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    smart00220
    Location:16268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14404
    Location:285349
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cd14079
    Location:13268
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    124568845..124642569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763901.1XP_008762123.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_008762123.1

    Conserved Domains (4) summary
    cd12200
    Location:305460
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    smart00220
    Location:1178
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14404
    Location:195259
    UBA_AID_AAPK2; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPKalpha-2)
    cl21453
    Location:1178
    PKc_like; Protein Kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    118363351..118429630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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