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Srebf1 sterol regulatory element binding transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 78968, updated on 17-Jan-2022

Summary

Official Symbol
Srebf1provided by RGD
Official Full Name
sterol regulatory element binding transcription factor 1provided by RGD
Primary source
RGD:69423
See related
Ensembl:ENSRNOG00000003463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ADD1; ADD-1; Srebp1; SREBP-1; SREBP-1c
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including response to peptide hormone; response to progesterone; and response to retinoic acid. Located in nucleus. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in disease of metabolism and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 594.1), Thymus (RPKM 279.1) and 9 other tissues See more
Orthologs
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Genomic context

See Srebf1 in Genome Data Viewer
Location:
10q22
Exon count:
20
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45007637..45029650, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46570996..46593021, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene dnaJ homolog subfamily A member 1-like Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene uncharacterized LOC102549418 Neighboring gene retinoic acid induced 1 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene GID complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sterol response element binding ISO
Inferred from Sequence Orthology
more info
 
enables sterol response element binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in SREBP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid localization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lung development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart rate by chemical signal ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid storage IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to food IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucagon IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin TAS
Traceable Author Statement
more info
PubMed 
involved_in response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sterol regulatory element-binding protein 1
Names
adipocyte determination- and differentiation-dependent factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276707.1NP_001263636.1  sterol regulatory element-binding protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001263636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P56720
    Related
    ENSRNOP00000050057.3, ENSRNOT00000047053.7
    Conserved Domains (1) summary
    cd00083
    Location:315372
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_001276708.1NP_001263637.1  sterol regulatory element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001263637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P56720
    Related
    ENSRNOP00000004753.6, ENSRNOT00000004753.6
    Conserved Domains (2) summary
    cd00083
    Location:291348
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam10146
    Location:146206
    zf-C4H2; Zinc finger-containing protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    45007637..45029650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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