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Mcam melanoma cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 78967, updated on 31-Oct-2021

Summary

Official Symbol
Mcamprovided by RGD
Official Full Name
melanoma cell adhesion moleculeprovided by RGD
Primary source
RGD:620463
See related
EnsemblRapid:ENSRNOG00000007726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD146; Muc18
Summary
may act as a cell adhesion molecule; may play a role in tumor growth and invasion [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 474.8), Heart (RPKM 232.4) and 9 other tissues See more
Orthologs
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Genomic context

See Mcam in Genome Data Viewer
Location:
8q22
Exon count:
16
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44479391..44487575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48472824..48481005)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 26 Neighboring gene uncharacterized LOC120094132 Neighboring gene Cbl proto-oncogene Neighboring gene coiled-coil domain containing 153

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cell surface glycoprotein MUC18
Names
gicerin
l-gicerin
melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034009.1NP_001029181.1  cell surface glycoprotein MUC18 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001029181.1

    Status: VALIDATED

    Source sequence(s)
    BC070916
    UniProtKB/Swiss-Prot
    Q9EPF2
    Related
    ENSRNOP00000069860.1, ENSRNOT00000090780.2
    Conserved Domains (4) summary
    pfam08205
    Location:141236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:348412
    Ig_3; Immunoglobulin domain
    cd00096
    Location:172177
    Ig; Ig strand C [structural motif]
    cl11960
    Location:452508
    Ig; Immunoglobulin domain
  2. NM_023983.3NP_076473.2  cell surface glycoprotein MUC18 isoform 1 precursor

    See identical proteins and their annotated locations for NP_076473.2

    Status: VALIDATED

    Source sequence(s)
    AB035506, BC070916
    UniProtKB/Swiss-Prot
    Q9EPF2
    Related
    ENSRNOP00000010464.5, ENSRNOT00000010463.7
    Conserved Domains (4) summary
    smart00408
    Location:359412
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:440515
    IG_like; Immunoglobulin like
    pfam08205
    Location:141236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:452515
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    44479391..44487575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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