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Pigt phosphatidylinositol glycan anchor biosynthesis, class T [ Mus musculus (house mouse) ]

Gene ID: 78928, updated on 6-Jun-2024

Summary

Official Symbol
Pigtprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Tprovided by MGI
Primary source
MGI:MGI:1926178
See related
Ensembl:ENSMUSG00000017721 AllianceGenome:MGI:1926178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NDAP; Ndap7; CGI-06; 2510012P17Rik; 4930534E15Rik
Summary
Involved in attachment of GPI anchor to protein. Acts upstream of or within neuron apoptotic process and neuron differentiation. Located in cytoplasmic vesicle. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 132.8), adrenal adult (RPKM 118.8) and 28 other tissues See more
Orthologs
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Genomic context

See Pigt in Genome Data Viewer
Location:
2 H3; 2 85.17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164339461..164350221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164497090..164508301)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene syndecan 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090 Neighboring gene STARR-seq mESC enhancer starr_06332 Neighboring gene predicted gene 14317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
GPI transamidase component PIG-T
Names
neuronal development-associated protein 7
phosphatidylinositol-glycan biosynthesis class T protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362644.2NP_001349573.1  GPI transamidase component PIG-T isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL591478
    Consensus CDS
    CCDS89578.1
    UniProtKB/TrEMBL
    B7ZC19
    Related
    ENSMUSP00000112577.2, ENSMUST00000117066.8
    Conserved Domains (1) summary
    pfam04113
    Location:36419
    Gpi16; Gpi16 subunit, GPI transamidase component
  2. NM_001362645.2NP_001349574.1  GPI transamidase component PIG-T isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL591478
    Conserved Domains (1) summary
    pfam04113
    Location:2301
    Gpi16; Gpi16 subunit, GPI transamidase component
  3. NM_001378795.1NP_001365724.1  GPI transamidase component PIG-T isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591478
    Conserved Domains (1) summary
    pfam04113
    Location:71478
    Gpi16; Gpi16 subunit, GPI transamidase component
  4. NM_001407281.1NP_001394210.1  GPI transamidase component PIG-T isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591478
    UniProtKB/Swiss-Prot
    A2A5G2, Q3U2X2, Q8BXQ2, Q99JA3
    UniProtKB/TrEMBL
    Q3U5R2
  5. NM_133779.3NP_598540.2  GPI transamidase component PIG-T isoform 1 precursor

    See identical proteins and their annotated locations for NP_598540.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL591478
    Consensus CDS
    CCDS17038.2
    UniProtKB/Swiss-Prot
    A2A5G2, Q3U2X2, Q8BXQ2, Q99JA3
    UniProtKB/TrEMBL
    Q3U5R2
    Related
    ENSMUSP00000099390.5, ENSMUST00000103101.11
    Conserved Domains (1) summary
    pfam04113
    Location:36572
    Gpi16; Gpi16 subunit, GPI transamidase component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164339461..164350221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)