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Pigt phosphatidylinositol glycan anchor biosynthesis, class T [ Mus musculus (house mouse) ]

Gene ID: 78928, updated on 26-Sep-2022

Summary

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Official Symbol
Pigtprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Tprovided by MGI
Primary source
MGI:MGI:1926178
See related
Ensembl:ENSMUSG00000017721 AllianceGenome:MGI:1926178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NDAP; Ndap7; CGI-06; 2510012P17Rik; 4930534E15Rik
Summary
Involved in attachment of GPI anchor to protein. Acts upstream of or within neuron apoptotic process and neuron differentiation. Located in cytoplasmic vesicle. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 132.8), adrenal adult (RPKM 118.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pigt in Genome Data Viewer
Location:
2; 2 H3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164339384..164350221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164497090..164508301)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene syndecan 4 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin (dystrobrevin binding protein 1) domain containing 2 Neighboring gene predicted gene, 36090 Neighboring gene predicted gene 14317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and identification of differentially expressed transcripts in primary culture of GABAergic neurons. Li Z, et al. Neurochem Res, 2001 Oct. PMID 11700951
  2. The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. Li HL, et al. FEBS Lett, 2006 Mar 20. PMID 16516892
  3. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI transamidase component PIG-T
Names
neuronal development-associated protein 7
phosphatidylinositol-glycan biosynthesis class T protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362644.2 → NP_001349573.1  GPI transamidase component PIG-T isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL591478
    Consensus CDS
    CCDS89578.1
    UniProtKB/TrEMBL
    B7ZC19
    Related
    ENSMUSP00000112577.2, ENSMUST00000117066.8
    Conserved Domains (1) summary
    pfam04113
    Location:36 → 419
    Gpi16; Gpi16 subunit, GPI transamidase component

  2. NM_001362645.2 → NP_001349574.1  GPI transamidase component PIG-T isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL591478
    Conserved Domains (1) summary
    pfam04113
    Location:2 → 301
    Gpi16; Gpi16 subunit, GPI transamidase component

  3. NM_001378795.1 → NP_001365724.1  GPI transamidase component PIG-T isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591478
    Conserved Domains (1) summary
    pfam04113
    Location:71 → 478
    Gpi16; Gpi16 subunit, GPI transamidase component

  4. NM_001407281.1 → NP_001394210.1  GPI transamidase component PIG-T isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591478
    UniProtKB/Swiss-Prot
    Q99JA3

  5. NM_133779.3 → NP_598540.2  GPI transamidase component PIG-T isoform 1 precursor

    See identical proteins and their annotated locations for NP_598540.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL591478
    Consensus CDS
    CCDS17038.2
    UniProtKB/Swiss-Prot
    Q8BXQ2, Q99JA3
    UniProtKB/TrEMBL
    Q3U5R2
    Related
    ENSMUSP00000099390.5, ENSMUST00000103101.11
    Conserved Domains (1) summary
    pfam04113
    Location:36 → 572
    Gpi16; Gpi16 subunit, GPI transamidase component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164339384..164350221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500421.5 → XP_006500484.3  GPI transamidase component PIG-T isoform X1

    Conserved Domains (1) summary
    pfam04113
    Location:54 → 585
    Gpi16; Gpi16 subunit, GPI transamidase component
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXQ2.2 GenPept UniProtKB/Swiss-Prot:Q8BXQ2

Gene LinkOut

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