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Misp mitotic spindle positioning [ Mus musculus (house mouse) ]

Gene ID: 78906, updated on 18-Sep-2024

Summary

Official Symbol
Mispprovided by MGI
Official Full Name
mitotic spindle positioningprovided by MGI
Primary source
MGI:MGI:1926156
See related
Ensembl:ENSMUSG00000035852 AllianceGenome:MGI:1926156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130017N09Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including establishment of centrosome localization; microtubule cytoskeleton organization involved in mitosis; and regulation of protein localization to cell cortex. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Predicted to colocalize with cortical actin cytoskeleton and mitotic spindle astral microtubule end. Is expressed in gut. Orthologous to human MISP (mitotic spindle positioning). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 126.6), colon adult (RPKM 99.2) and 3 other tissues See more
Orthologs
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Genomic context

See Misp in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79656853..79666286)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79821019..79830452)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene follistatin-like 3 Neighboring gene serine protease 57 Neighboring gene predicted gene, 40713 Neighboring gene paralemmin Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79314980-79315089 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene phospholipid phosphatase related 3 Neighboring gene microRNA 6910

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of centrosome localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in organelle localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cortical actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitotic spindle astral microtubule end ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitotic spindle astral microtubule end ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitotic interactor and substrate of PLK1
Names
mitotic spindle positioning protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030218.2NP_084494.1  mitotic interactor and substrate of PLK1

    See identical proteins and their annotated locations for NP_084494.1

    Status: VALIDATED

    Source sequence(s)
    AC124407
    Consensus CDS
    CCDS23992.1
    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Related
    ENSMUSP00000130071.2, ENSMUST00000169041.9
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79656853..79666286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514328.1XP_006514391.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514391.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  2. XM_006514330.1XP_006514393.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514393.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Related
    ENSMUSP00000151529.2, ENSMUST00000219305.2
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  3. XM_006514329.1XP_006514392.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514392.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Related
    ENSMUSP00000048893.5, ENSMUST00000046833.5
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  4. XM_006514331.1XP_006514394.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514394.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  5. XM_006514333.5XP_006514396.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514396.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  6. XM_006514332.4XP_006514395.1  mitotic interactor and substrate of PLK1 isoform X1

    See identical proteins and their annotated locations for XP_006514395.1

    UniProtKB/Swiss-Prot
    Q3UI04, Q9D279
    Conserved Domains (1) summary
    pfam15304
    Location:294643
    AKAP2_C; A-kinase anchor protein 2 C-terminus