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Aacs acetoacetyl-CoA synthetase [ Mus musculus (house mouse) ]

Gene ID: 78894, updated on 27-Nov-2024

Summary

Official Symbol
Aacsprovided by MGI
Official Full Name
acetoacetyl-CoA synthetaseprovided by MGI
Primary source
MGI:MGI:1926144
See related
Ensembl:ENSMUSG00000029482 AllianceGenome:MGI:1926144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SUR5; 2210408B16Rik
Summary
Predicted to enable acetoacetate-CoA ligase activity and medium-chain fatty acid-CoA ligase activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; positive regulation of insulin secretion; and response to oleic acid. Predicted to be located in cytosol. Is expressed in alimentary system; eye; hemolymphoid system; nervous system; and urinary system. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 107.7), subcutaneous fat pad adult (RPKM 90.4) and 27 other tissues See more
Orthologs
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Genomic context

See Aacs in Genome Data Viewer
Location:
5 G1.1; 5 64.24 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125552937..125594469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125475873..125517405)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene Bri3 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6383 Neighboring gene STARR-positive B cell enhancer ABC_E6384 Neighboring gene predicted gene, 40325 Neighboring gene transmembrane protein 132B Neighboring gene STARR-seq mESC enhancer starr_14382 Neighboring gene predicted gene, 32811 Neighboring gene microRNA 12200

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetoacetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetoacetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetoacetate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables medium-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oleic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acetoacetyl-CoA synthetase
NP_084486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030210.2NP_084486.1  acetoacetyl-CoA synthetase

    See identical proteins and their annotated locations for NP_084486.1

    Status: VALIDATED

    Source sequence(s)
    AC119268
    Consensus CDS
    CCDS19687.1
    UniProtKB/Swiss-Prot
    A1IG47, Q3TCL8, Q3UD39, Q9D2R0
    Related
    ENSMUSP00000031445.4, ENSMUST00000031445.5
    Conserved Domains (2) summary
    cd05943
    Location:40663
    AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
    TIGR01217
    Location:16671
    ac_ac_CoA_syn; acetoacetyl-CoA synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    125552937..125594469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)