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Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 [ Mus musculus (house mouse) ]

Gene ID: 78830, updated on 17-Sep-2019

Summary

Official Symbol
Slc25a12provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, Aralar), member 12provided by MGI
Primary source
MGI:MGI:1926080
See related
Ensembl:ENSMUSG00000027010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI839531; BB129864; 2610002D09Rik; B230107K20Rik
Expression
Ubiquitous expression in heart adult (RPKM 17.8), cerebellum adult (RPKM 11.2) and 27 other tissues See more
Orthologs

Genomic context

See Slc25a12 in Genome Data Viewer
Location:
2; 2 C2
Exon count:
20
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71274270..71367781, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (71112352..71205611, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39576 Neighboring gene dynein cytoplasmic 1 intermediate chain 2 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene VISTA enhancer mm55 Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-aspartate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate-aspartate shuttle IMP
Inferred from Mutant Phenotype
more info
PubMed 
malate-aspartate shuttle ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane HDA PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 

General protein information

Preferred Names
calcium-binding mitochondrial carrier protein Aralar1
Names
mitochondrial aspartate glutamate carrier 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172436.4NP_766024.1  calcium-binding mitochondrial carrier protein Aralar1

    See identical proteins and their annotated locations for NP_766024.1

    Status: VALIDATED

    Source sequence(s)
    AK083156, BP765755, BX284624
    Consensus CDS
    CCDS16113.1
    UniProtKB/Swiss-Prot
    Q8BH59
    Related
    ENSMUSP00000122103.1, ENSMUST00000151937.7
    Conserved Domains (4) summary
    pfam00153
    Location:522609
    Mito_carr; Mitochondrial carrier protein
    cd15900
    Location:91115
    EFh_MICU; EF-hand motif [structural motif]
    cl25352
    Location:14119
    EFh_PEF; The penta-EF hand (PEF) family
    cl28896
    Location:91160
    EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    71274270..71367781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252254.1XP_030108114.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

  2. XM_011239853.3XP_011238155.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

    Conserved Domains (2) summary
    PTZ00169
    Location:241514
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:433520
    Mito_carr; Mitochondrial carrier protein
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