Tsc22d4 Tsc22 domain family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsc22d4provided by MGI
Official Full Name: Tsc22 domain family, member 4provided by MGI
Primary source: MGI:MGI:1926079
See related: Ensembl:ENSMUSG00000029723 AllianceGenome:MGI:1926079
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tilz2; Spacdr; AI415410; Thg-1pit; 0610009M14Rik; 1700023B23Rik
Summary: Involved in several processes, including glucose homeostasis; negative regulation of transcription by RNA polymerase II; and neuron projection extension. Acts upstream of or within response to osmotic stress. Located in several cellular components, including dendrite; nucleus; and synapse. Is expressed in several structures, including early conceptus; genitourinary system; and nervous system. Orthologous to several human genes including TSC22D4 (TSC22 domain family member 4). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in thymus adult (RPKM 94.0), heart adult (RPKM 40.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.64 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137744274..137758011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137745969..137768453)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSC22D4 interacts with Akt1 to regulate glucose metabolism.
Title: TSC22D4 interacts with Akt1 to regulate glucose metabolism.
Liver-specific ablation of TSC22D4 triggered hypertriglyceridemia through the induction of hepatic VLDL secretion.
Title: TSC22D4 is a molecular output of hepatic wasting metabolism.
In vitro TSC22D4 silencing with small interfering (si)RNAs blocks granule cell differentiation and inhibits neurite elongation in neuroblastoma cells, pinpointing the relevance of this protein to granule cell differentiation.
Title: Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation.
Thg-1 pit is relevant to specification, proliferation/migration, differentiation, and mature function of granule/interneuron cells in different brain districts [Thg-1 pit]
Title: Thg-1 pit gene expression in granule cells of the developing mouse brain and in their synaptic targets, mature Purkinje, and mitral cells.
Results suggest that THG-1pit is involved in the induction of granule neuron apoptosis.
Title: THG-1pit moves to nucleus at the onset of cerebellar granule neurons apoptosis.
TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
Title: Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.
TSC22D4 is stably upregulated by hyperosmolality in mIMCD3 cells and increased in renal papilla compared with cortex.
Title: Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493099

NoName (e-PCR)
- UniSTS:235342

NoName (e-PCR)
- UniSTS:548466

AI415410 (e-PCR)
- UniSTS:159463

Readthrough Gm57848

Readthrough gene: Gm57848, Included gene: Spacdr

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TSC22 domain family protein 4

Names: TSC22 domain family 4; TSC22-related inducible leucine zipper 2; TSC22-related-inducible leucine zipper protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.