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ADGRL1 adhesion G protein-coupled receptor L1 [ Bos taurus (domestic cattle) ]

Gene ID: 788252, updated on 19-Nov-2025
Official Symbol
ADGRL1provided by VGNC
Official Full Name
adhesion G protein-coupled receptor L1provided by VGNC
Primary source
VGNC:VGNC:25671
See related
BGD:BT11915; EnsemblRapid:ENSBTAG00070016425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
LPHN1
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ADGRL1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (11510052..11560787)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447643 Neighboring gene uncharacterized LOC100335404 Neighboring gene uncharacterized LOC100848715 Neighboring gene anti-silencing function 1B histone chaperone

Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution. Matsushita H, et al. FEBS Lett, 1999 Jan 29. PMID 10025961
  2. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. Lelianova VG, et al. J Biol Chem, 1997 Aug 22. PMID 9261169
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables latrotoxin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
calcium-independent alpha-latrotoxin receptor 1
latrophilin-1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113728.1 → NP_001107200.1  adhesion G protein-coupled receptor L1 precursor

    See identical proteins and their annotated locations for NP_001107200.1

    Status: PROVISIONAL

    Source sequence(s)
    AF111098
    UniProtKB/Swiss-Prot
    O97830, O97831
    UniProtKB/TrEMBL
    A0A452DHZ2
    Related
    ENSBTAP00070021725.1, ENSBTAT00070036943.1
    Conserved Domains (7) summary
    smart00303
    Location:797 → 849
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476 → 539
    HormR; Domain present in hormone receptors
    pfam00002
    Location:857 → 1092
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1112 → 1472
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    11510052..11560787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888482.1 → XP_059744465.1  adhesion G protein-coupled receptor L1 isoform X1

    UniProtKB/TrEMBL
    A0A452DHZ2

  2. XM_005208626.5 → XP_005208683.1  adhesion G protein-coupled receptor L1 isoform X2

    See identical proteins and their annotated locations for XP_005208683.1

    UniProtKB/TrEMBL
    A0A452DHZ2
    Related
    ENSBTAP00070021730.1, ENSBTAT00070036953.1
    Conserved Domains (7) summary
    smart00303
    Location:792 → 844
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    pfam00002
    Location:852 → 1087
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1107 → 1467
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:545 → 766
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  3. XM_010806701.3 → XP_010805003.1  adhesion G protein-coupled receptor L1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MN27
    Conserved Domains (7) summary
    smart00303
    Location:688 → 740
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:367 → 430
    HormR; Domain present in hormone receptors
    pfam02354
    Location:1003 → 1363
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:440 → 664
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16007
    Location:747 → 1004
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:33 → 289
    OLF; Olfactomedin-like domain
    cl25429
    Location:310 → 392
    PALP; Pyridoxal-phosphate dependent enzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97831.1 GenPept UniProtKB/Swiss-Prot:O97831

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials