U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gmip Gem-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 78816, updated on 5-Mar-2024

Summary

Official Symbol
Gmipprovided by MGI
Official Full Name
Gem-interacting proteinprovided by MGI
Primary source
MGI:MGI:1926066
See related
Ensembl:ENSMUSG00000036246 AllianceGenome:MGI:1926066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5031419I10Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and negative regulation of GTPase activity. Predicted to be active in plasma membrane. Is expressed in brain; hippocampus; ovary; testis; and thyroid gland. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 38.0), thymus adult (RPKM 25.8) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gmip in Genome Data Viewer
Location:
8 B3.3; 8 33.88 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70260912..70274520)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69808298..69821870)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 866 Neighboring gene STARR-positive B cell enhancer ABC_E6643 Neighboring gene STARR-positive B cell enhancer ABC_E6644 Neighboring gene ATPase type 13A1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:72332338-72332525 Neighboring gene predicted gene, 33695 Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene pre B cell leukemia homeobox 4 Neighboring gene STARR-seq mESC enhancer starr_21749

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198101.1NP_932769.1  GEM-interacting protein

    See identical proteins and their annotated locations for NP_932769.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057037
    Consensus CDS
    CCDS22350.1
    UniProtKB/Swiss-Prot
    Q6P9S3, Q6PGG2
    Related
    ENSMUSP00000045676.9, ENSMUST00000036074.15
    Conserved Domains (4) summary
    TIGR02473
    Location:87217
    flagell_FliJ; flagellar export protein FliJ
    smart00109
    Location:491536
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:548751
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:112312
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70260912..70274520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509799.5XP_006509862.1  GEM-interacting protein isoform X6

    Conserved Domains (3) summary
    smart00109
    Location:595640
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:652732
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:216416
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_030243857.2XP_030099717.2  GEM-interacting protein isoform X4

    Related
    ENSMUSP00000116542.2, ENSMUST00000123453.2
    Conserved Domains (3) summary
    cd04408
    Location:652855
    RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...
    cd20816
    Location:595644
    C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
    cl12013
    Location:216416
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_006509797.5XP_006509860.2  GEM-interacting protein isoform X1

    Conserved Domains (3) summary
    smart00109
    Location:491536
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:548751
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:112312
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_006509798.5XP_006509861.2  GEM-interacting protein isoform X3

    Conserved Domains (3) summary
    smart00109
    Location:491536
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cd04408
    Location:548751
    RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...
    cl12013
    Location:112312
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_036154385.1XP_036010278.1  GEM-interacting protein isoform X5

    Conserved Domains (3) summary
    cd20816
    Location:358407
    C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
    cl02570
    Location:415618
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:58179
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_036154386.1XP_036010279.1  GEM-interacting protein isoform X5

    Conserved Domains (3) summary
    cd20816
    Location:358407
    C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
    cl02570
    Location:415618
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:58179
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_030243856.2XP_030099716.1  GEM-interacting protein isoform X2

    Conserved Domains (3) summary
    smart00109
    Location:503548
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:560763
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:124324
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_003947356.2 RNA Sequence