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Cfap61 cilia and flagella associated protein 61 [ Mus musculus (house mouse) ]

Gene ID: 78774, updated on 28-Mar-2023

Summary

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Official Symbol
Cfap61provided by MGI
Official Full Name
cilia and flagella associated protein 61provided by MGI
Primary source
MGI:MGI:1926024
See related
Ensembl:ENSMUSG00000037143 AllianceGenome:MGI:1926024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930529M08Rik
Summary
Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Orthologous to human CFAP61 (cilia and flagella associated protein 61). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.7) and lung adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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See Cfap61 in Genome Data Viewer
Location:
2; 2 G1
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145776677..146056955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145934757..146215035)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene predicted gene, 34629 Neighboring gene RIKEN cDNA A930019D19 gene Neighboring gene Ral GTPase activating protein, alpha subunit 2 (catalytic) Neighboring gene insulinoma-associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella. Huang T, et al. Sci Bull (Beijing), 2020 May 30. PMID 36659204
  2. Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia. Hu T, et al. J Med Genet, 2023 Feb. PMID 35387802
  3. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Liu S, et al. Development, 2021 Dec 1. PMID 34792097
  4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
    Title: Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
  2. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.
    Title: CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC58680, MGC129508, MGC129509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369121.1 → NP_001356050.1  cilia- and flagella-associated protein 61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672100, AL732467, AL935056
    Consensus CDS
    CCDS89562.1
    UniProtKB/TrEMBL
    B2FDI8
    Related
    ENSMUSP00000118411.2, ENSMUST00000133433.8
    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:15 → 268
    DUF4821; Domain of unknown function (DUF4821)

  2. NM_175280.3 → NP_780489.2  cilia- and flagella-associated protein 61 isoform 2

    See identical proteins and their annotated locations for NP_780489.2

    Status: VALIDATED

    Source sequence(s)
    AK038772
    Consensus CDS
    CCDS50736.1
    UniProtKB/TrEMBL
    B7ZCD6
    Related
    ENSMUSP00000112099.2, ENSMUST00000116398.8
    Conserved Domains (1) summary
    pfam16092
    Location:15 → 237
    DUF4821; Domain of unknown function (DUF4821)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145776677..146056955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252249.1 → XP_030108109.1  cilia- and flagella-associated protein 61 isoform X1

    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  2. XM_030252246.2 → XP_030108106.1  cilia- and flagella-associated protein 61 isoform X2

    Conserved Domains (2) summary
    COG1251
    Location:658 → 777
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  3. XM_036162725.1 → XP_036018618.1  cilia- and flagella-associated protein 61 isoform X7

    Conserved Domains (1) summary
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  4. XM_030252245.1 → XP_030108105.1  cilia- and flagella-associated protein 61 isoform X1

    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  5. XM_036162724.1 → XP_036018617.1  cilia- and flagella-associated protein 61 isoform X6

    Conserved Domains (2) summary
    COG1251
    Location:419 → 538
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 27
    DUF4821; Domain of unknown function (DUF4821)

  6. XM_030252247.1 → XP_030108107.1  cilia- and flagella-associated protein 61 isoform X3

    Conserved Domains (2) summary
    COG1251
    Location:596 → 715
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:2 → 204
    DUF4821; Domain of unknown function (DUF4821)

  7. XM_030252250.1 → XP_030108110.1  cilia- and flagella-associated protein 61 isoform X5

    Conserved Domains (2) summary
    COG1251
    Location:464 → 583
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 72
    DUF4821; Domain of unknown function (DUF4821)

  8. XM_030252248.2 → XP_030108108.1  cilia- and flagella-associated protein 61 isoform X4

    Conserved Domains (2) summary
    COG1251
    Location:556 → 675
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 164
    DUF4821; Domain of unknown function (DUF4821)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEL2.2 GenPept UniProtKB/Swiss-Prot:Q8CEL2

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