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Mctp1 multiple C2 domains, transmembrane 1 [ Mus musculus (house mouse) ]

Gene ID: 78771, updated on 24-Apr-2022

Summary

Official Symbol
Mctp1provided by MGI
Official Full Name
multiple C2 domains, transmembrane 1provided by MGI
Primary source
MGI:MGI:1926021
See related
Ensembl:ENSMUSG00000021596 AllianceGenome:MGI:1926021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810465F10Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; negative regulation of response to oxidative stress; and regulation of neurotransmitter secretion. Predicted to be located in recycling endosome. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of membrane. Is expressed in brain. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.3), ovary adult (RPKM 4.5) and 9 other tissues See more
Orthologs
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Genomic context

See Mctp1 in Genome Data Viewer
Location:
13; 13 C1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76530481..77181403)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (76382362..77033284)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (76522409..77171071)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 81, member B Neighboring gene predicted gene, 31219 Neighboring gene predicted gene, 31516 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene predicted gene, 46431 Neighboring gene predicted gene, 24519 Neighboring gene predicted gene, 21959 Neighboring gene vacuolar protein sorting 4a pseudogene Neighboring gene jagunal homolog 1 pseudogene Neighboring gene VISTA enhancer mm1556 Neighboring gene chromatin modifying protein 2A pseudogene Neighboring gene RIKEN cDNA 2210408I21 gene Neighboring gene 60S ribosomal protein L17-like Neighboring gene SMC5-SMC6 complex localization factor 1 Neighboring gene VISTA enhancer mm881

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multiple C2 and transmembrane domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377108.1NP_001364037.1  multiple C2 and transmembrane domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112671, AC124362, AC140345, AC161266
    Conserved Domains (4) summary
    cd04042
    Location:40161
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:203318
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:358476
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:619680
    PRT_C; Plant phosphoribosyltransferase C-terminal
  2. NM_030174.3NP_084450.3  multiple C2 and transmembrane domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC112671, AC124362, AC140345, AC154788, AC161266
    Consensus CDS
    CCDS26656.1
    Related
    ENSMUSP00000118958.2, ENSMUST00000125209.8
    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:423538
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:578696
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:839924
    PRT_C; Plant phosphoribosyltransferase C-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    76530481..77181403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517462.4XP_006517525.3  multiple C2 and transmembrane domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:459574
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:614732
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:875960
    PRT_C; Plant phosphoribosyltransferase C-terminal
  2. XM_006517466.4XP_006517529.3  multiple C2 and transmembrane domain-containing protein 1 isoform X4

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:459574
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:614732
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:875936
    PRT_C; Plant phosphoribosyltransferase C-terminal
  3. XM_006517464.4XP_006517527.3  multiple C2 and transmembrane domain-containing protein 1 isoform X3

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:439554
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:594712
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:855940
    PRT_C; Plant phosphoribosyltransferase C-terminal
  4. XM_036158226.1XP_036014119.1  multiple C2 and transmembrane domain-containing protein 1 isoform X6

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:439554
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:594712
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:855916
    PRT_C; Plant phosphoribosyltransferase C-terminal
  5. XM_006517463.4XP_006517526.3  multiple C2 and transmembrane domain-containing protein 1 isoform X2

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:443558
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:598716
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:859944
    PRT_C; Plant phosphoribosyltransferase C-terminal
  6. XM_036158227.1XP_036014120.1  multiple C2 and transmembrane domain-containing protein 1 isoform X7

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:423538
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:578696
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:839900
    PRT_C; Plant phosphoribosyltransferase C-terminal
  7. XM_006517467.4XP_006517530.3  multiple C2 and transmembrane domain-containing protein 1 isoform X5

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:410525
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:565683
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:826911
    PRT_C; Plant phosphoribosyltransferase C-terminal
  8. XM_017315643.2XP_017171132.1  multiple C2 and transmembrane domain-containing protein 1 isoform X8

    Conserved Domains (4) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:410525
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:565683
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:826887
    PRT_C; Plant phosphoribosyltransferase C-terminal
  9. XM_006517472.4XP_006517535.3  multiple C2 and transmembrane domain-containing protein 1 isoform X14

    Conserved Domains (3) summary
    cd04042
    Location:260381
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:459574
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cl14603
    Location:614633
    C2; C2 domain
  10. XM_006517468.5XP_006517531.1  multiple C2 and transmembrane domain-containing protein 1 isoform X9

    Conserved Domains (4) summary
    cd04042
    Location:40161
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:239354
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:394512
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:655740
    PRT_C; Plant phosphoribosyltransferase C-terminal
  11. XM_006517469.5XP_006517532.1  multiple C2 and transmembrane domain-containing protein 1 isoform X10

    Conserved Domains (4) summary
    cd04042
    Location:40161
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:223338
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:378496
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:639724
    PRT_C; Plant phosphoribosyltransferase C-terminal
  12. XM_030247469.2XP_030103329.1  multiple C2 and transmembrane domain-containing protein 1 isoform X11

    Related
    ENSMUSP00000105212.3, ENSMUST00000109583.9
    Conserved Domains (4) summary
    cd04042
    Location:40161
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:203318
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:358476
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:619704
    PRT_C; Plant phosphoribosyltransferase C-terminal
  13. XM_006517471.5XP_006517534.1  multiple C2 and transmembrane domain-containing protein 1 isoform X13

    Conserved Domains (4) summary
    cd04042
    Location:40161
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:190305
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:345463
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:606691
    PRT_C; Plant phosphoribosyltransferase C-terminal
  14. XM_006517470.3XP_006517533.1  multiple C2 and transmembrane domain-containing protein 1 isoform X12

    See identical proteins and their annotated locations for XP_006517533.1

    Conserved Domains (4) summary
    cd04042
    Location:3124
    C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08376
    Location:202317
    C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    cd08377
    Location:357475
    C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
    pfam08372
    Location:618703
    PRT_C; Plant phosphoribosyltransferase C-terminal