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Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 78752, updated on 2-Nov-2024

Summary

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Official Symbol
Csgalnact2provided by MGI
Official Full Name
chondroitin sulfate N-acetylgalactosaminyltransferase 2provided by MGI
Primary source
MGI:MGI:1926002
See related
Ensembl:ENSMUSG00000042042 AllianceGenome:MGI:1926002
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galnact2; 4632415D10Rik
Summary
Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within chondroitin sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in brain; cartilage; knee; and limb long bone. Orthologous to human CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 6.5), lung adult (RPKM 4.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Csgalnact2 in Genome Data Viewer
Location:
6 F1; 6 55.86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118084413..118116132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118107452..118139140, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene RasGEF domain family, member 1A Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044 Neighboring gene predicted gene, 23908 Neighboring gene STARR-positive B cell enhancer ABC_E6475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:118117270-118117379 Neighboring gene STARR-positive B cell enhancer ABC_E2800 Neighboring gene ret proto-oncogene Neighboring gene STARR-seq mESC enhancer starr_17135 Neighboring gene RIKEN cDNA 1700069P05 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain. Adhikara IM, et al. Arterioscler Thromb Vasc Biol, 2021 Mar. PMID 33504177
  2. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. Adhikara IM, et al. Biochem Biophys Res Commun, 2019 Jan 29. PMID 30579596
  3. GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. Izumikawa T, et al. J Biol Chem, 2015 Feb 27. PMID 25568321, Free PMC Article
  4. Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury. Takeuchi K, et al. Nat Commun, 2013. PMID 24220492, Free PMC Article
  5. Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Izumikawa T, et al. Biochem J, 2011 Mar 1. PMID 21138417

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
    Title: Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
  2. Chondroitin sulfate N-acetylgalactosaminyltransferase 2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages.
    Title: Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dermatan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dermatan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chondroitin sulfate N-acetylgalactosaminyltransferase 2
Names
beta4GalNAcT-2
chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2
chondroitin sulfate GalNAcT-2
galNAcT-2
NP_001349078.1
NP_084441.3
XP_006506840.1
XP_036008295.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362149.1 → NP_001349078.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS20469.1
    UniProtKB/Swiss-Prot
    Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
    Conserved Domains (1) summary
    cl11394
    Location:75 → 516
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. NM_030165.3 → NP_084441.3  chondroitin sulfate N-acetylgalactosaminyltransferase 2

    See identical proteins and their annotated locations for NP_084441.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK019496, AK028045, BC060169
    Consensus CDS
    CCDS20469.1
    UniProtKB/Swiss-Prot
    Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
    Related
    ENSMUSP00000039819.9, ENSMUST00000049344.15
    Conserved Domains (1) summary
    cl11394
    Location:75 → 516
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118084413..118116132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152402.1 → XP_036008295.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:67 → 482
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_006506777.5 → XP_006506840.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006506840.1

    UniProtKB/Swiss-Prot
    Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
    Conserved Domains (1) summary
    cl11394
    Location:75 → 516
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1F4.1 GenPept UniProtKB/Swiss-Prot:Q8C1F4

Gene LinkOut

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