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Filip1l filamin A interacting protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 78749, updated on 8-Nov-2022

Summary

Official Symbol
Filip1lprovided by MGI
Official Full Name
filamin A interacting protein 1-likeprovided by MGI
Primary source
MGI:MGI:1925999
See related
Ensembl:ENSMUSG00000043336 AllianceGenome:MGI:1925999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Doc1; 4631422O05Rik
Summary
Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in pectoral girdle and thoracic body wall musculature. Orthologous to human FILIP1L (filamin A interacting protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 18.6), limb E14.5 (RPKM 7.5) and 19 other tissues See more
Orthologs
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Genomic context

See Filip1l in Genome Data Viewer
Location:
16; 16 C1.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (57173640..57393167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57353277..57572804)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene predicted gene, 53930 Neighboring gene microRNA 1970b Neighboring gene collagen, type VIII, alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
filamin A-interacting protein 1-like
Names
downregulated in ovarian cancer 1-like
protein down-regulated in ovarian cancer 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040397.4NP_001035487.2  filamin A-interacting protein 1-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC144776, BY739488, CT030226
    Consensus CDS
    CCDS37366.2
    UniProtKB/TrEMBL
    E0CYH7
    Related
    ENSMUSP00000124179.2, ENSMUST00000159816.8
    Conserved Domains (3) summary
    COG0419
    Location:85678
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:539842
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09727
    Location:64246
    CortBP2; Cortactin-binding protein-2
  2. NM_001177871.1NP_001171342.1  filamin A-interacting protein 1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC144776, AK019472
    Consensus CDS
    CCDS49877.1
    UniProtKB/TrEMBL
    E0CYM1
    Related
    ENSMUSP00000124069.2, ENSMUST00000159414.2
    Conserved Domains (5) summary
    COG1340
    Location:87360
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam00901
    Location:189302
    Orbi_VP5; Orbivirus outer capsid protein VP5
    pfam06009
    Location:53139
    Laminin_II; Laminin Domain II
    pfam17061
    Location:668890
    PARM; PARM
    cl03075
    Location:380431
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    57173640..57393167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249333.2XP_030105193.1  filamin A-interacting protein 1-like isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:138502
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:4220
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam17061
    Location:722944
    PARM