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Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Mus musculus (house mouse) ]

Gene ID: 78689, updated on 5-Mar-2024

Summary

Official Symbol
Naa35provided by MGI
Official Full Name
N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by MGI
Primary source
MGI:MGI:1925939
See related
Ensembl:ENSMUSG00000021555 AllianceGenome:MGI:1925939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mak10; A330021G12Rik; A330027C19Rik; C030004C14Rik
Summary
Involved in smooth muscle cell proliferation. Located in cytoplasm. Is expressed in embryo. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 22.3), CNS E11.5 (RPKM 21.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
13 B2; 13 31.87 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59733147..59782612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59585333..59634798)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_34711 Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene STARR-seq mESC enhancer starr_34713 Neighboring gene STARR-seq mESC enhancer starr_34715 Neighboring gene STARR-seq mESC enhancer starr_34717 Neighboring gene golgi membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_34719 Neighboring gene RIKEN cDNA 4921517D22 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NatC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
MAK10 homolog, amino-acid N-acetyltransferase subunit
Nalpha acetyltransferase 35
embryonic growth-associated protein
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384120.1NP_001371049.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469
    UniProtKB/Swiss-Prot
    Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  2. NM_001384121.1NP_001371050.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  3. NM_030153.2NP_084429.2  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

    See identical proteins and their annotated locations for NP_084429.2

    Status: VALIDATED

    Source sequence(s)
    BC056435, BY100294
    Consensus CDS
    CCDS26575.1
    UniProtKB/Swiss-Prot
    Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
    Related
    ENSMUSP00000022038.8, ENSMUST00000022038.15
    Conserved Domains (1) summary
    pfam04112
    Location:46181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RNA

  1. NR_168734.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134869, AC135469

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    59733147..59782612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247467.2XP_030103327.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    Conserved Domains (1) summary
    pfam04112
    Location:189324
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
  2. XM_036158225.1XP_036014118.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

    Conserved Domains (1) summary
    pfam04112
    Location:189324
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RNA

  1. XR_004938075.1 RNA Sequence

  2. XR_004938076.1 RNA Sequence