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Plekhj1 pleckstrin homology domain containing, family J member 1 [ Mus musculus (house mouse) ]

Gene ID: 78670, updated on 26-Sep-2022

Summary

Official Symbol
Plekhj1provided by MGI
Official Full Name
pleckstrin homology domain containing, family J member 1provided by MGI
Primary source
MGI:MGI:1925920
See related
Ensembl:ENSMUSG00000035278 AllianceGenome:MGI:1925920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530063M10Rik
Summary
Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Is expressed in brain; gonad; liver; musculature; and spleen. Orthologous to human PLEKHJ1 (pleckstrin homology domain containing J1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.2), limb E14.5 (RPKM 24.8) and 28 other tissues See more
Orthologs
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Genomic context

See Plekhj1 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80631933..80634460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80796099..80798626, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53592 Neighboring gene DOT1-like, histone H3 methyltransferase (S. cerevisiae) Neighboring gene VISTA enhancer mm200 Neighboring gene splicing factor 3a, subunit 2 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family J member 1
Names
PH domain-containing family J member 1
guanine nucleotide releasing protein x

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023900.3NP_076389.2  pleckstrin homology domain-containing family J member 1

    See identical proteins and their annotated locations for NP_076389.2

    Status: VALIDATED

    Source sequence(s)
    AC166937
    Consensus CDS
    CCDS48640.1
    UniProtKB/Swiss-Prot
    Q9D240, Q9EPF0
    Related
    ENSMUSP00000042334.6, ENSMUST00000036805.7
    Conserved Domains (2) summary
    cd13258
    Location:1112
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:25108
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80631933..80634460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314166.2XP_017169655.1  pleckstrin homology domain-containing family J member 1 isoform X3

    Conserved Domains (1) summary
    cd13258
    Location:1106
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain
  2. XM_030245395.1XP_030101255.1  pleckstrin homology domain-containing family J member 1 isoform X5

    Conserved Domains (1) summary
    cl17171
    Location:167
    PH-like; Pleckstrin homology-like domain
  3. XM_006514326.3XP_006514389.1  pleckstrin homology domain-containing family J member 1 isoform X1

    Conserved Domains (1) summary
    cd13258
    Location:1112
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain
  4. XM_006514327.4XP_006514390.1  pleckstrin homology domain-containing family J member 1 isoform X4

    Conserved Domains (1) summary
    cl17171
    Location:167
    PH-like; Pleckstrin homology-like domain
  5. XM_017314165.1XP_017169654.1  pleckstrin homology domain-containing family J member 1 isoform X2

    Conserved Domains (1) summary
    cd13258
    Location:1106
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain