Bola3 bolA-like 3 (E. coli) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bola3provided by MGI
Official Full Name: bolA-like 3 (E. coli)provided by MGI
Primary source: MGI:MGI:1925903
See related: Ensembl:ENSMUSG00000045160 AllianceGenome:MGI:1925903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810056O20Rik
Summary: Predicted to be located in cytosol; mitochondrion; and nuclear body. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 34.5), liver E14.5 (RPKM 31.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83326129..83337118)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83349147..83360136)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that in vivo, pharmacological knockdown of endothelial BOLA3 and targeted overexpression of BOLA3 promotes histological and hemodynamic manifestations of pulmonary hypertension
Title: BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Bola3 gene: The Bola3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 464 organisms have orthologs with human gene Bola3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein maturation by [4Fe-4S] cluster transfer	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of iron-sulfur cluster assembly complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bolA-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363772.1 → NP_001350701.1 bolA-like protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC159713, BC049748, CO039842

Consensus CDS

CCDS90068.1

UniProtKB/TrEMBL

E9Q705

Related

ENSMUSP00000113439.2, ENSMUST00000122216.8

Conserved Domains (1) summary

cl00386
Location:23 → 94

BolA; BolA-like protein
NM_001363773.1 → NP_001350702.1 bolA-like protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC159713, CF981442, CO039842

Consensus CDS

CCDS90069.1

UniProtKB/TrEMBL

E9PX89

Related

ENSMUSP00000112582.2, ENSMUST00000120040.8

Conserved Domains (1) summary

cl00386
Location:64 → 135

BolA; BolA-like protein
NM_175277.5 → NP_780486.1 bolA-like protein 3 isoform 1

See identical proteins and their annotated locations for NP_780486.1

Status: VALIDATED

Source sequence(s)

AC159713

Consensus CDS

CCDS20278.1

UniProtKB/Swiss-Prot

Q8CEI1

UniProtKB/TrEMBL

A0A6P5Q394, Q14A77

Related

ENSMUSP00000118348.2, ENSMUST00000136501.2

Conserved Domains (1) summary

cl00386
Location:38 → 109

BolA; BolA-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83326129..83337118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152401.1 → XP_036008294.1 bolA-like protein 3 isoform X1

Conserved Domains (1) summary

cl00386
Location:38 → 90

BolA; BolA-like protein
XM_017321834.1 → XP_017177323.1 bolA-like protein 3 isoform X2

Conserved Domains (1) summary

cl00386
Location:65 → 136

BolA; BolA-like protein