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Uvrag UV radiation resistance associated gene [ Mus musculus (house mouse) ]

Gene ID: 78610, updated on 12-May-2024

Summary

Official Symbol
Uvragprovided by MGI
Official Full Name
UV radiation resistance associated geneprovided by MGI
Primary source
MGI:MGI:1925860
See related
Ensembl:ENSMUSG00000035354 AllianceGenome:MGI:1925860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Uvrag1; Uvragl; 9530039D02Rik
Summary
Enables SH3 domain binding activity and SNARE binding activity. Involved in DNA repair; chromosome segregation; and microtubule cytoskeleton organization. Acts upstream of or within SNARE complex assembly and viral entry into host cell. Located in phagocytic vesicle. Part of protein-containing complex. Is expressed in midgut; smooth muscle tissue; and thyroid gland. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 13.8), thymus adult (RPKM 12.8) and 28 other tissues See more
Orthologs
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Genomic context

See Uvrag in Genome Data Viewer
Location:
7 E1; 7 53.92 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98535949..98790373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98886742..99141167, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33770 Neighboring gene wingless-type MMTV integration site family, member 11 Neighboring gene predicted gene, 33827 Neighboring gene predicted gene 8149 Neighboring gene STARR-seq mESC enhancer starr_19641 Neighboring gene predicted gene, 23479 Neighboring gene STARR-seq mESC enhancer starr_19643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106235549-106235826 Neighboring gene predicted gene, 33882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106289887-106290074 Neighboring gene STARR-positive B cell enhancer ABC_E10454 Neighboring gene STARR-positive B cell enhancer ABC_E3734 Neighboring gene STARR-positive B cell enhancer ABC_E9023 Neighboring gene diacylglycerol O-acyltransferase 2 Neighboring gene monoacylglycerol O-acyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within SNARE complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via classical nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of Golgi location ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within symbiont entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of DNA-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in lytic vacuole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IPI
Inferred from Physical Interaction
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UV radiation resistance-associated protein
Names
UV radiation resistance associated protein
UV radiation resistance-associated gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178635.3NP_848750.3  UV radiation resistance-associated protein

    See identical proteins and their annotated locations for NP_848750.3

    Status: VALIDATED

    Source sequence(s)
    AK030814, AK078085, BB530952, BY024873
    Consensus CDS
    CCDS21476.1
    UniProtKB/Swiss-Prot
    Q8BVI8, Q8C0K8, Q8K245
    UniProtKB/TrEMBL
    Q8BXW8
    Related
    ENSMUSP00000045297.9, ENSMUST00000037968.10
    Conserved Domains (2) summary
    cd00030
    Location:44118
    C2; C2 domain
    pfam10186
    Location:183441
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    98535949..98790373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508349.4XP_006508412.1  UV radiation resistance-associated protein isoform X1

    UniProtKB/TrEMBL
    Q8BXW8
    Conserved Domains (1) summary
    pfam10186
    Location:140398
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
  2. XM_030243116.2XP_030098976.1  UV radiation resistance-associated protein isoform X2

    Conserved Domains (1) summary
    pfam10186
    Location:4173
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
  3. XM_036153589.1XP_036009482.1  UV radiation resistance-associated protein isoform X2

    Conserved Domains (1) summary
    pfam10186
    Location:4173
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14