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CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 [ Homo sapiens (human) ]

Gene ID: 786, updated on 4-May-2020

Summary

Official Symbol
CACNG1provided by HGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 1provided by HGNC
Primary source
HGNC:HGNC:1405
See related
Ensembl:ENSG00000108878 MIM:114209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACNLG
Summary
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]
Expression
Biased expression in esophagus (RPKM 1.9), prostate (RPKM 1.8) and 2 other tissues See more
Orthologs

Genomic context

See CACNG1 in Genome Data Viewer
Location:
17q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (67044554..67056797)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65040652..65052913)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 446 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 4 Neighboring gene helicase with zinc finger Neighboring gene Sharpr-MPRA regulatory region 4721 Neighboring gene ribosomal protein L36a pseudogene 48

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of calcium channel, voltage-dependent, gamma subunit 1 (CACNG1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcoplasmic reticulum calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-1 subunit
Names
L-type calcium channel gamma polypeptide
calcium channel, voltage-dependent, gamma subunit 1
dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
neuronal dihydropyridine-sensitive calcium channel gamma subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000727.4NP_000718.1  voltage-dependent calcium channel gamma-1 subunit

    See identical proteins and their annotated locations for NP_000718.1

    Status: REVIEWED

    Source sequence(s)
    AC005544, AF086300, BC113486, DA898357
    Consensus CDS
    CCDS11668.1
    UniProtKB/Swiss-Prot
    Q06432
    Related
    ENSP00000226021.3, ENST00000226021.5
    Conserved Domains (1) summary
    pfam13903
    Location:19189
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    67044554..67056797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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