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Htra3 HtrA serine peptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 78558, updated on 5-Jan-2023

Summary

Official Symbol
Htra3provided by MGI
Official Full Name
HtrA serine peptidase 3provided by MGI
Primary source
MGI:MGI:1925808
See related
Ensembl:ENSMUSG00000029096 AllianceGenome:MGI:1925808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prsp; Tasp; 2210021K23Rik; 9530081K03Rik
Summary
Enables serine-type peptidase activity. Involved in negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and proteolysis. Predicted to be located in extracellular region. Is expressed in decidua; decidua basalis; and decidua capsularis. Orthologous to human HTRA3 (HtrA serine peptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 98.7), subcutaneous fat pad adult (RPKM 87.5) and 14 other tissues See more
Orthologs
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Genomic context

See Htra3 in Genome Data Viewer
Location:
5; 5 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35809370..35837157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35652026..35679813, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene polo like kinase, pseudogene 1 Neighboring gene tRNA methyltransferase 44 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene predicted gene, 31888 Neighboring gene actin-binding LIM protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease HTRA3
Names
high-temperature requirement factor A3
pregnancy-related serine protease
probable serine protease HTRA3
toll-associated serine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042615.2NP_001036080.1  serine protease HTRA3 isoform b precursor

    See identical proteins and their annotated locations for NP_001036080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI481644, AK008764, AK035194, AY156509
    Consensus CDS
    CCDS39071.1
    UniProtKB/Swiss-Prot
    Q9D236
    UniProtKB/TrEMBL
    A0A8C6HUU9
    Related
    ENSMUSP00000109871.3, ENSMUST00000114233.3
    Conserved Domains (3) summary
    pfam00219
    Location:3182
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:87132
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:181325
    Trypsin_2; Trypsin-like peptidase domain
  2. NM_030127.3NP_084403.2  serine protease HTRA3 isoform a precursor

    See identical proteins and their annotated locations for NP_084403.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK008764, AK020653, AK035194, AY156509
    Consensus CDS
    CCDS19233.1
    UniProtKB/Swiss-Prot
    Q6YDR0, Q9D236
    UniProtKB/TrEMBL
    A0A8C6N133
    Related
    ENSMUSP00000084910.4, ENSMUST00000087629.10
    Conserved Domains (4) summary
    cd00987
    Location:361446
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00219
    Location:3182
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:87132
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:181325
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35809370..35837157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504186.2XP_006504249.1  serine protease HTRA3 isoform X1

    Conserved Domains (3) summary
    TIGR02037
    Location:149440
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:3182
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:95132
    Kazal_2; Kazal-type serine protease inhibitor domain
  2. XM_030254908.2XP_030110768.1  serine protease HTRA3 isoform X3

    Conserved Domains (1) summary
    TIGR02037
    Location:1247
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
  3. XM_011240796.4XP_011239098.1  serine protease HTRA3 isoform X2

    Conserved Domains (1) summary
    TIGR02037
    Location:1255
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

RNA

  1. XR_004942587.1 RNA Sequence