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FGF21 fibroblast growth factor 21 [ Bos taurus (domestic cattle) ]

Gene ID: 785576, updated on 30-Jan-2025
Official Symbol
FGF21provided by VGNC
Official Full Name
fibroblast growth factor 21provided by VGNC
Primary source
VGNC:VGNC:28977
See related
BGD:BT10468; EnsemblRapid:ENSBTAG00070036775
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
FGF8C
Orthologs
human mouse all
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See FGF21 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (55382969..55384706)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene izumo sperm-oocyte fusion 1 Neighboring gene fucosyltransferase 1 Neighboring gene branched chain amino acid transaminase 2 Neighboring gene uncharacterized LOC101903281 Neighboring gene hydroxysteroid 17-beta dehydrogenase 14

Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows. Xu C, et al. BMC Vet Res, 2015 Oct 24. PMID 26497746, Free PMC Article
  2. Expression of fibroblast growth factor 21 in the liver of dairy cows in the transition period and during lactation. Schlegel G, et al. J Anim Physiol Anim Nutr (Berl), 2013 Oct. PMID 22805261
  3. Plasma FGF21 is elevated by the intense lipid mobilization of lactation. Schoenberg KM, et al. Endocrinology, 2011 Dec. PMID 21990311
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
    Title: Expression of fibroblast growth factor 21 in the liver of dairy cows in the transition period and during lactation.
  2. RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
    Title: The relationship between Fibroblast Growth Factor-21 and characteristic parameters related to energy balance in dairy cows.
  3. liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
    Title: Plasma FGF21 is elevated by the intense lipid mobilization of lactation.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
fibroblast growth factor 21
Names
fibroblast growth factor 8C

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    55382969..55384706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005219486.5 → XP_005219543.1  fibroblast growth factor 21

    See identical proteins and their annotated locations for XP_005219543.1

    UniProtKB/TrEMBL
    A0AAA9RTQ2, E1BDA6
    Related
    ENSBTAP00070049871.1, ENSBTAT00070082371.1
    Conserved Domains (1) summary
    cl00060
    Location:47 → 164
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
Nucleotide Protein Strain
Heading Accession and Version

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