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FZD5 frizzled class receptor 5 [ Homo sapiens (human) ]

Gene ID: 7855, updated on 9-Apr-2026
Official Symbol
FZD5provided by HGNC
Official Full Name
frizzled class receptor 5provided by HGNC
Primary source
HGNC:HGNC:4043
See related
Ensembl:ENSG00000163251 MIM:601723; AllianceGenome:HGNC:4043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HFZ5; C2orf31; MCOPCB11
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 15.4), duodenum (RPKM 10.5) and 19 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See FZD5 in Genome Data Viewer
Location:
2q33.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207762598..207769906, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208236810..208244116, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208627322..208634630, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208576168-208577164 Neighboring gene cyclin Y like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208631909-208632465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208632466-208633023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208635695-208636515 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:208636987-208637462 Neighboring gene microRNA 4775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208647704-208648204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208660472-208661457 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208661458-208662442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208666419-208666920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208666921-208667420 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208675729-208676550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17048 Neighboring gene pleckstrin homology domain containing M3 Neighboring gene HNF1 motif-containing MPRA enhancer 152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:208713897-208714396 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:208772908-208774107 Neighboring gene Sharpr-MPRA regulatory region 2767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:208835249-208835782 Neighboring gene RNA, U6 small nuclear 360, pseudogene Neighboring gene ribosomal protein L9 pseudogene 14

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth. Zheng S, et al. Adv Sci (Weinh), 2022 Oct. PMID 35975457, Free PMC Article
  2. Confirmation of FZD5 implication in a cohort of 50 patients with ocular coloboma. Aubert-Mucca M, et al. Eur J Hum Genet, 2021 Jan. PMID 32737437, Free PMC Article
  3. Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Tsutsumi N, et al. Elife, 2020 Aug 7. PMID 32762848, Free PMC Article
  4. Upregulation of FZD5 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Epigenetic Modification. Kim JY, et al. Mol Cells, 2019 Apr 30. PMID 31082802, Free PMC Article
  5. FZD5 contributes to TNBC proliferation, DNA damage repair and stemness. Sun Y, et al. Cell Death Dis, 2020 Dec 12. PMID 33311446, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis.
    Title: circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis.
  2. Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification.
    Title: Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification.
  3. Insilco prediction of the role of the FriZZled5 gene in colorectal cancer.
    Title: Insilco prediction of the role of the FriZZled5 gene in colorectal cancer.
  4. A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
    Title: A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
  5. Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
    Title: Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
  6. Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity.
    Title: Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity.
  7. Aberrant Cholesterol Metabolism and Wnt/beta-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.
    Title: Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.
  8. RNF43 R117fs mutant positively regulates Wnt/beta-catenin signaling by failing to internalize FZD expressed on the cell surface.
    Title: RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface.
  9. Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.
    Title: Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.
  10. WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
    Title: WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microphthalmia/coloboma 11
MedGen: C5935584 OMIM: 620731 GeneReviews: Not available
Compare labs

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC129692, DKFZp434E2135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity IC
Inferred by Curator
more info
 PubMed 
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Wnt-protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables amyloid-beta binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Spemann organizer formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anterior/posterior axis specification, embryo IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryonic axis specification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to mitochondrion HMP PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitophagy HMP PubMed 
involved_in synapse assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
frizzled-5
Names
Wnt receptor
frizzled 5, seven transmembrane spanning receptor
frizzled family receptor 5
fz-5
fzE5
seven-transmembrane receptor frizzled-5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050642.2 RefSeqGene

    Range
    5000..12308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003468.4 → NP_003459.2  frizzled-5 precursor

    See identical proteins and their annotated locations for NP_003459.2

    Status: REVIEWED

    Source sequence(s)
    AC096772
    Consensus CDS
    CCDS33366.1
    UniProtKB/Swiss-Prot
    A8K2X1, B2RCZ1, Q13467, Q53R22
    Related
    ENSP00000354607.3, ENST00000295417.4
    Conserved Domains (2) summary
    cd07460
    Location:29 → 156
    CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
    cd15249
    Location:225 → 535
    7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    207762598..207769906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    208236810..208244116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030804.1: Suppressed sequence

    Description
    NM_030804.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13467.2 GenPept UniProtKB/Swiss-Prot:Q13467

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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