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FZD5 frizzled class receptor 5 [ Homo sapiens (human) ]

Gene ID: 7855, updated on 20-Dec-2019

Summary

Official Symbol
FZD5provided by HGNC
Official Full Name
frizzled class receptor 5provided by HGNC
Primary source
HGNC:HGNC:4043
See related
Ensembl:ENSG00000163251 MIM:601723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HFZ5; C2orf31
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 15.4), duodenum (RPKM 10.5) and 19 other tissues See more
Orthologs

Genomic context

See FZD5 in Genome Data Viewer
Location:
2q33.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (207753889..207769906, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208627310..208634143, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 2 Neighboring gene RNA, U6 small nuclear 664, pseudogene Neighboring gene cyclin Y like 1 Neighboring gene microRNA 4775 Neighboring gene pleckstrin homology domain containing M3 Neighboring gene HNF1 motif-containing MPRA enhancer 152 Neighboring gene RNA, U6 small nuclear 360, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129692, DKFZp434E2135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IC
Inferred by Curator
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding TAS
Traceable Author Statement
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Spemann organizer formation IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior axis specification, embryo IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
chorionic trophoblast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
embryonic axis specification IDA
Inferred from Direct Assay
more info
PubMed 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to mitochondrion HMP PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of tumor necrosis factor secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagy of mitochondrion HMP PubMed 
regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of chorionic trophoblast cell proliferation IEA
Inferred from Electronic Annotation
more info
 
synapse assembly TAS
Traceable Author Statement
more info
PubMed 
syncytiotrophoblast cell differentiation involved in labyrinthine layer development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
frizzled-5
Names
Wnt receptor
frizzled 5, seven transmembrane spanning receptor
frizzled family receptor 5
fz-5
fzE5
seven-transmembrane receptor frizzled-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050642.1 RefSeqGene

    Range
    5001..11834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003468.4NP_003459.2  frizzled-5 precursor

    See identical proteins and their annotated locations for NP_003459.2

    Status: REVIEWED

    Source sequence(s)
    AC096772
    Consensus CDS
    CCDS33366.1
    UniProtKB/Swiss-Prot
    Q13467
    Related
    ENSP00000354607.3, ENST00000295417.4
    Conserved Domains (2) summary
    cd07460
    Location:29156
    CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
    cd15249
    Location:225535
    7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    207753889..207769906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453130.1XP_024308898.1  frizzled-5 isoform X1

    Conserved Domains (2) summary
    cd07460
    Location:29156
    CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
    cd15249
    Location:225535
    7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030804.1: Suppressed sequence

    Description
    NM_030804.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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