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MALL mal, T cell differentiation protein like [ Homo sapiens (human) ]

Gene ID: 7851, updated on 17-Jun-2024

Summary

Official Symbol
MALLprovided by HGNC
Official Full Name
mal, T cell differentiation protein likeprovided by HGNC
Primary source
HGNC:HGNC:6818
See related
Ensembl:ENSG00000144063 MIM:602022; AllianceGenome:HGNC:6818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BENE
Summary
This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 101.4), duodenum (RPKM 83.6) and 10 other tissues See more
Orthologs
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Genomic context

See MALL in Genome Data Viewer
Location:
2q13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110083870..110118139, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110506185..110514140, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110841447..110875716, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110800236-110800801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110804612-110805458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110806307-110807152 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110811814-110812352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110812353-110812891 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110821474-110821974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110839142-110839642 Neighboring gene microRNA 4267 Neighboring gene microRNA 4436b-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:110863055-110864254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110872579-110873386 Neighboring gene nephrocystin 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:110906815-110908014 Neighboring gene NANOG hESC enhancer GRCh37_chr2:110925133-110925634 Neighboring gene ACTR1A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16369 Neighboring gene mitoregulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies MALL, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC4419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371559.1NP_001358488.1  MAL-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013268
    Conserved Domains (1) summary
    pfam01284
    Location:31144
    MARVEL; Membrane-associating domain
  2. NM_001371560.1NP_001358489.1  MAL-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013268
  3. NM_005434.5NP_005425.1  MAL-like protein isoform 1

    See identical proteins and their annotated locations for NP_005425.1

    Status: VALIDATED

    Source sequence(s)
    AC013268
    Consensus CDS
    CCDS2085.1
    UniProtKB/Swiss-Prot
    B3KWR6, Q13021, Q9BTU0
    UniProtKB/TrEMBL
    B3KPQ3
    Related
    ENSP00000272462.2, ENST00000272462.3
    Conserved Domains (1) summary
    pfam01284
    Location:23148
    MARVEL; Membrane-associating domain

RNA

  1. NR_189746.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CP068276
  2. NR_189747.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CP068276

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110083870..110118139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445801.1XP_047301757.1  MAL-like protein isoform X1

    UniProtKB/Swiss-Prot
    B3KWR6, Q13021, Q9BTU0
    UniProtKB/TrEMBL
    B3KPQ3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    110506185..110514140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)