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MALL mal, T cell differentiation protein like [ Homo sapiens (human) ]

Gene ID: 7851, updated on 5-Aug-2018

Summary

Official Symbol
MALLprovided by HGNC
Official Full Name
mal, T cell differentiation protein likeprovided by HGNC
Primary source
HGNC:HGNC:6818
See related
Ensembl:ENSG00000144063 MIM:602022; Vega:OTTHUMG00000131196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BENE
Summary
This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 101.4), duodenum (RPKM 83.6) and 10 other tissues See more
Orthologs

Genomic context

See MALL in Genome Data Viewer
Location:
2q13
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (110083870..110118139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110841447..110874143, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373986 Neighboring gene microRNA 4267 Neighboring gene microRNA 4436b-1 Neighboring gene nephrocystin 1 Neighboring gene ARP1 actin related protein 1 homolog A pseudogene Neighboring gene mitoregulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies MALL, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cholesterol homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005434.4NP_005425.1  MAL-like protein

    Status: VALIDATED

    Source sequence(s)
    AC013268, AK125647, BC003179, U17077
    Consensus CDS
    CCDS2085.1
    UniProtKB/Swiss-Prot
    Q13021
    Related
    ENSP00000272462.2, OTTHUMP00000161842, ENST00000272462.2, OTTHUMT00000253921
    Conserved Domains (1) summary
    pfam01284
    Location:23148
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    110083870..110118139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511809.1XP_011510111.1  MAL-like protein isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:31144
    MARVEL; Membrane-associating domain
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