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IL1R2 interleukin 1 receptor type 2 [ Homo sapiens (human) ]

Gene ID: 7850, updated on 21-Jun-2020

Summary

Official Symbol
IL1R2provided by HGNC
Official Full Name
interleukin 1 receptor type 2provided by HGNC
Primary source
HGNC:HGNC:5994
See related
Ensembl:ENSG00000115590 MIM:147811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2
Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Expression
Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues See more
Orthologs

Genomic context

See IL1R2 in Genome Data Viewer
Location:
2q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101991805..102028544)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102608306..102644885)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene uncharacterized LOC107985926 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC47725

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 alpha secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-1 receptor type 2
Names
CD121 antigen-like family member B
IL-1 type II receptor
IL-1R-beta
antigen CDw121b
interleukin 1 receptor type II variant 3
interleukin-1 receptor beta
interleukin-1 receptor type II
type II interleukin-1 receptor, beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261419.2NP_001248348.1  interleukin-1 receptor type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001248348.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' splice site which introduces an immediate stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005035, AC007165, U64094
    Consensus CDS
    CCDS58719.1
    UniProtKB/Swiss-Prot
    P27930
    Related
    ENSP00000414611.1, ENST00000441002.1
    Conserved Domains (4) summary
    cd05756
    Location:30125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:136230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02826
    Location:27228
    PHA02826; IL-1 receptor-like protein; Provisional
    cl11960
    Location:241285
    Ig; Immunoglobulin domain
  2. NM_004633.4NP_004624.1  interleukin-1 receptor type 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007165, BC039031
    Consensus CDS
    CCDS2054.1
    UniProtKB/Swiss-Prot
    P27930
    Related
    ENSP00000330959.3, ENST00000332549.8
    Conserved Domains (3) summary
    cd05897
    Location:136230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241341
    ig; Immunoglobulin domain
    cd05756
    Location:30125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

RNA

  1. NR_048564.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005035, AC007165, DC380050, X59770

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    101991805..102028544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712736.3XP_006712799.1  interleukin-1 receptor type 2 isoform X2

    Conserved Domains (4) summary
    cd05756
    Location:55150
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:161255
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02785
    Location:31352
    PHA02785; IL-beta-binding protein; Provisional
    pfam00047
    Location:266366
    ig; Immunoglobulin domain
  2. XM_006712734.3XP_006712797.1  interleukin-1 receptor type 2 isoform X4

    See identical proteins and their annotated locations for XP_006712797.1

    UniProtKB/Swiss-Prot
    P27930
    Conserved Domains (3) summary
    cd05897
    Location:136230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241341
    ig; Immunoglobulin domain
    cd05756
    Location:30125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  3. XM_024453129.1XP_024308897.1  interleukin-1 receptor type 2 isoform X6

    Conserved Domains (2) summary
    cd05897
    Location:51145
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    cl28655
    Location:8242
    PHA02785; IL-beta-binding protein; Provisional
  4. XM_017004889.1XP_016860378.1  interleukin-1 receptor type 2 isoform X6

    Conserved Domains (2) summary
    cd05897
    Location:51145
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    cl28655
    Location:8242
    PHA02785; IL-beta-binding protein; Provisional
  5. XM_011511803.2XP_011510105.1  interleukin-1 receptor type 2 isoform X3

    Conserved Domains (3) summary
    cd05897
    Location:142236
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:247347
    ig; Immunoglobulin domain
    cl11960
    Location:79131
    Ig; Immunoglobulin domain
  6. XM_011511805.3XP_011510107.1  interleukin-1 receptor type 2 isoform X5

    Conserved Domains (3) summary
    cd05897
    Location:116210
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:221321
    ig; Immunoglobulin domain
    cl11960
    Location:53105
    Ig; Immunoglobulin domain
  7. XM_011511804.3XP_011510106.1  interleukin-1 receptor type 2 isoform X4

    See identical proteins and their annotated locations for XP_011510106.1

    UniProtKB/Swiss-Prot
    P27930
    Conserved Domains (3) summary
    cd05897
    Location:136230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241341
    ig; Immunoglobulin domain
    cd05756
    Location:30125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  8. XM_011511801.2XP_011510103.1  interleukin-1 receptor type 2 isoform X1

    Conserved Domains (4) summary
    cd05756
    Location:73168
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:179273
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02785
    Location:49370
    PHA02785; IL-beta-binding protein; Provisional
    pfam00047
    Location:284384
    ig; Immunoglobulin domain
  9. XM_011511807.1XP_011510109.1  interleukin-1 receptor type 2 isoform X7

    Related
    ENSP00000408415.1, ENST00000457817.5
    Conserved Domains (3) summary
    cd05756
    Location:73168
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:179272
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02826
    Location:70271
    PHA02826; IL-1 receptor-like protein; Provisional
  10. XM_011511808.2XP_011510110.1  interleukin-1 receptor type 2 isoform X8

    Conserved Domains (2) summary
    smart00410
    Location:82179
    IG_like; Immunoglobulin like
    pfam00047
    Location:79179
    ig; Immunoglobulin domain

RNA

  1. XR_923024.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173343.1: Suppressed sequence

    Description
    NM_173343.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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