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Ntf5 neurotrophin 5 [ Mus musculus (house mouse) ]

Gene ID: 78405, updated on 8-Feb-2024

Summary

Official Symbol
Ntf5provided by MGI
Official Full Name
neurotrophin 5provided by MGI
Primary source
MGI:MGI:97381
See related
Ensembl:ENSMUSG00000074121 AllianceGenome:MGI:97381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NT4; NT-4; NT-5; Ntf4; NT4/5; Ntf-5; 2900040K06Rik
Summary
This gene encodes a secreted protein belonging to the neurotrophin family of structurally related molecules that play a crucial role in the control of neuronal numbers and of dendritic growth. The encoded preproprotein undergoes post-translational processing to generate non-covalently associated homodimeric functional protein. Mice deficient in the encoded protein exhibit a loss of sensory neurons in the nodose-petrosal and geniculate ganglia, have deficits in long-term memory and hippocampal long-lasting long-term potentiation. [provided by RefSeq, Oct 2015]
Expression
Broad expression in lung adult (RPKM 1.4), ovary adult (RPKM 1.1) and 15 other tissues See more
Orthologs
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Genomic context

See Ntf5 in Genome Data Viewer
Location:
7 B3; 7 29.3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45063119..45066603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45413695..45417179)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein 70 (U1) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52651210-52651456 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 7 Neighboring gene stabilizer of axonemal microtubules 3 Neighboring gene luteinizing hormone beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neurotrophin p75 receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ganglion mother cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innervation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mechanoreceptor differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sensory organ boundary specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within taste bud development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
neurotrophin-4
Names
neutrophic factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198190.1NP_937833.1  neurotrophin-4 preproprotein

    See identical proteins and their annotated locations for NP_937833.1

    Status: REVIEWED

    Source sequence(s)
    BC052191
    Consensus CDS
    CCDS21241.1
    UniProtKB/Swiss-Prot
    Q80VU4
    Related
    ENSMUSP00000057916.7, ENSMUST00000058879.8
    Conserved Domains (1) summary
    pfam00243
    Location:88205
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45063119..45066603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541312.5XP_006541375.1  neurotrophin-4 isoform X1

    See identical proteins and their annotated locations for XP_006541375.1

    UniProtKB/Swiss-Prot
    Q80VU4
    Conserved Domains (1) summary
    pfam00243
    Location:88205
    NGF; Nerve growth factor family
  2. XM_006541313.4XP_006541376.1  neurotrophin-4 isoform X1

    See identical proteins and their annotated locations for XP_006541376.1

    UniProtKB/Swiss-Prot
    Q80VU4
    Conserved Domains (1) summary
    pfam00243
    Location:88205
    NGF; Nerve growth factor family