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Pla2g4d phospholipase A2, group IVD [ Mus musculus (house mouse) ]

Gene ID: 78390, updated on 27-Nov-2024

Summary

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Official Symbol
Pla2g4dprovided by MGI
Official Full Name
phospholipase A2, group IVDprovided by MGI
Primary source
MGI:MGI:1925640
See related
Ensembl:ENSMUSG00000070719 AllianceGenome:MGI:1925640
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pla2delta; cPLA2delta; 2610311B01Rik
Summary
Enables phospholipase A2 activity. Predicted to be involved in glycerophospholipid catabolic process. Located in cytoplasm. Orthologous to human PLA2G4D (phospholipase A2 group IVD). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 4.0), testis adult (RPKM 3.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Pla2g4d in Genome Data Viewer
Location:
2 E5; 2 60.31 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120096347..120119678, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120265866..120289069, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene EH-domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05504 Neighboring gene STARR-positive B cell enhancer ABC_E226 Neighboring gene phospholipase A2, group IVE Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVF Neighboring gene VPS39 HOPS complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120178706-120178815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A(2) coordinates acute wound healing and repair. MacKnight HP, et al. Sci Signal, 2019 Dec 3. PMID 31796632, Free PMC Article
  2. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair.
    Title: The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A(2) coordinates acute wound healing and repair.
  2. murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
    Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytosolic phospholipase A2 delta
Names
cPLA2-delta
NP_001019308.1
XP_006500476.1
XP_011238151.1
XP_036018615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024137.1 → NP_001019308.1  cytosolic phospholipase A2 delta

    See identical proteins and their annotated locations for NP_001019308.1

    Status: PROVISIONAL

    Source sequence(s)
    AB195276
    Consensus CDS
    CCDS16617.1
    UniProtKB/Swiss-Prot
    A2AQJ1, Q3TJC5, Q50L43
    UniProtKB/TrEMBL
    Q14CI2
    Related
    ENSMUSP00000092252.5, ENSMUST00000094665.5
    Conserved Domains (3) summary
    cd04036
    Location:32 → 151
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:283 → 758
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    cl11396
    Location:278 → 814
    Patatin_and_cPLA2; Patatins and Phospholipases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120096347..120119678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500413.5 → XP_006500476.1  cytosolic phospholipase A2 delta isoform X1

    UniProtKB/TrEMBL
    Q14CI2, Q14DK8
    Conserved Domains (2) summary
    pfam18695
    Location:24 → 131
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:130 → 666
    Patatin_and_cPLA2; Patatins and Phospholipases

  2. XM_011239849.3 → XP_011238151.1  cytosolic phospholipase A2 delta isoform X2

    Conserved Domains (2) summary
    pfam18695
    Location:5 → 95
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:94 → 630
    Patatin_and_cPLA2; Patatins and Phospholipases

  3. XM_036162722.1 → XP_036018615.1  cytosolic phospholipase A2 delta isoform X3

    Conserved Domains (3) summary
    cd04036
    Location:32 → 151
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:172 → 279
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:278 → 633
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q50L43.3 GenPept UniProtKB/Swiss-Prot:Q50L43

Gene LinkOut

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