JAG1 jagged canonical Notch ligand 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: JAG1provided by VGNC
Official Full Name: jagged canonical Notch ligand 1provided by VGNC
Primary source: VGNC:VGNC:30361
See related: BGD:BT10345; EnsemblRapid:ENSBTAG00070018724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (3939809..3984202, complement)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_17827-17828:1024946457:1 (e-PCR)
- UniSTS:268416

PMC111189P2 (e-PCR)
- UniSTS:270221

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein jagged-1

Names: jagged 1 (Alagille syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191178.3 → NP_001178107.1 protein jagged-1 precursor

See identical proteins and their annotated locations for NP_001178107.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000013

UniProtKB/TrEMBL

E1BDN7

Related

ENSBTAP00070025285.1, ENSBTAT00070042351.1

Conserved Domains (5) summary

smart00215
Location:863 → 930

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:629 → 665

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:748 → 777

EGF; EGF-like domain

pfam01414
Location:167 → 229

DSL; Delta serrate ligand

pfam07657
Location:32 → 107

MNNL; N terminus of Notch ligand