U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BTG2 BTG anti-proliferation factor 2 [ Homo sapiens (human) ]

Gene ID: 7832, updated on 18-Sep-2024

Summary

Official Symbol
BTG2provided by HGNC
Official Full Name
BTG anti-proliferation factor 2provided by HGNC
Primary source
HGNC:HGNC:1131
See related
Ensembl:ENSG00000159388 MIM:601597; AllianceGenome:HGNC:1131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC3; APRO1; TIS21
Summary
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 185.2), esophagus (RPKM 183.2) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BTG2 in Genome Data Viewer
Location:
1q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (203305519..203309602)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (202568370..202572442)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203274647..203278730)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:203256086-203257285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2343 Neighboring gene long intergenic non-protein coding RNA 1353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203265487-203265988 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:203268313-203268517 Neighboring gene BTG2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2345 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203275924-203276866 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203276867-203277809 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10869 Neighboring gene RNA, U6 small nuclear 487, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203293504-203294428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2349 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:203297814-203298450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:203311519-203312021 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:203315005-203315665 Neighboring gene fibromodulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of BTG family, member 2 (BTG2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of BTG family, member 2 (BTG2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126063, MGC126064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to phorbol 13-acetate 12-myristate IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein BTG2
Names
B-cell translocation gene 2
BTG family member 2
NGF-inducible anti-proliferative protein PC3
nerve growth factor-inducible anti-proliferative
pheochromacytoma cell-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046929.1 RefSeqGene

    Range
    4984..9067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006763.3NP_006754.1  protein BTG2

    See identical proteins and their annotated locations for NP_006754.1

    Status: REVIEWED

    Source sequence(s)
    AL513326
    Consensus CDS
    CCDS1437.1
    UniProtKB/Swiss-Prot
    A0A024R986, P78543, Q3KR25, Q5VUT0
    Related
    ENSP00000290551.4, ENST00000290551.5
    Conserved Domains (1) summary
    pfam07742
    Location:9122
    BTG; BTG family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    203305519..203309602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    202568370..202572442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)