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Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [ Mus musculus (house mouse) ]

Gene ID: 78255, updated on 6-Nov-2022

Summary

Official Symbol
Ralgps2provided by MGI
Official Full Name
Ral GEF with PH domain and SH3 binding motif 2provided by MGI
Primary source
MGI:MGI:1925505
See related
Ensembl:ENSMUSG00000026594 AllianceGenome:MGI:1925505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810020P17Rik; 2210408F11Rik; 4921528G01Rik; 9130014M22Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction and small GTPase mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; eye; limb bud; and limb segment. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 13.7), CNS E14 (RPKM 8.2) and 27 other tissues See more
Orthologs
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Genomic context

See Ralgps2 in Genome Data Viewer
Location:
1; 1 G3
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156631736..156767422, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156804166..156939850, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39683 Neighboring gene PCNA-associated factor pseudogene Neighboring gene angiopoietin-like 1 Neighboring gene RIKEN cDNA 4930439D14 gene Neighboring gene predicted gene, 39685 Neighboring gene predicted gene, 30568

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Ral protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-specific guanine nucleotide-releasing factor RalGPS2
Names
ral GEF with PH domain and SH3-binding motif 2
ralA exchange factor RalGPS2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159965.1NP_001153437.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_001153437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549, BC052663, CJ104104
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Related
    ENSMUSP00000063872.7, ENSMUST00000063199.13
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  2. NM_001159966.1NP_001153438.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_001153438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Related
    ENSMUSP00000130581.2, ENSMUST00000171292.8
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  3. NM_001159967.1NP_001153439.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform b

    See identical proteins and their annotated locations for NP_001153439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC138109, AK169368, CJ104104
    Consensus CDS
    CCDS48406.1
    UniProtKB/Swiss-Prot
    Q9ERD6
    Related
    ENSMUSP00000027886.8, ENSMUST00000027886.14
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  4. NM_001159968.1NP_001153440.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform c

    See identical proteins and their annotated locations for NP_001153440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC138109, AK036803, CJ104104
    Consensus CDS
    CCDS48405.1
    UniProtKB/Swiss-Prot
    Q9ERD6
    Related
    ENSMUSP00000132533.2, ENSMUST00000172057.8
    Conserved Domains (3) summary
    smart00147
    Location:21251
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:431546
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:430540
    PH; PH domain
  5. NM_001357391.1NP_001344320.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC138109
    Conserved Domains (2) summary
    cd13310
    Location:300415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  6. NM_001357392.1NP_001344321.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC138109
    Conserved Domains (2) summary
    cd13310
    Location:300415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  7. NM_023884.4NP_076373.3  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_076373.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549, CJ104104
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Related
    ENSMUSP00000139645.2, ENSMUST00000191605.7
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156631736..156767422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243663.2XP_030099523.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  2. XM_006497033.2XP_006497096.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  3. XM_030243662.1XP_030099522.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  4. XM_030243657.1XP_030099517.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  5. XM_030243660.1XP_030099520.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  6. XM_030243669.1XP_030099529.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

    Conserved Domains (2) summary
    cd13310
    Location:300415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  7. XM_030243656.2XP_030099516.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  8. XM_030243664.2XP_030099524.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  9. XM_030243667.1XP_030099527.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

    Conserved Domains (2) summary
    cd13310
    Location:300415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  10. XM_036154413.1XP_036010306.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X5

    Conserved Domains (2) summary
    cd13310
    Location:235350
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:155
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
  11. XM_006497029.4XP_006497092.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497092.1

    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  12. XM_006497028.5XP_006497091.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497091.1

    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Related
    ENSMUSP00000140342.2, ENSMUST00000188656.7
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  13. XM_006497032.5XP_006497095.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497095.1

    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  14. XM_006497030.4XP_006497093.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497093.1

    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Related
    ENSMUSP00000139618.2, ENSMUST00000185198.7
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
  15. XM_006497031.5XP_006497094.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497094.1

    UniProtKB/Swiss-Prot
    Q9D2Y7, Q9ERD6
    Conserved Domains (2) summary
    smart00147
    Location:45286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RNA

  1. XR_003947313.2 RNA Sequence

  2. XR_373625.4 RNA Sequence