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Phf23 PHD finger protein 23 [ Mus musculus (house mouse) ]

Gene ID: 78246, updated on 4-Dec-2022

Summary

Official Symbol
Phf23provided by MGI
Official Full Name
PHD finger protein 23provided by MGI
Primary source
MGI:MGI:1925496
See related
Ensembl:ENSMUSG00000018572 AllianceGenome:MGI:1925496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JUNE-1
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Predicted to act upstream of or within autophagy. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human PHF23 (PHD finger protein 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.3), limb E14.5 (RPKM 10.2) and 28 other tissues See more
Orthologs
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Genomic context

See Phf23 in Genome Data Viewer
Location:
11 B3; 11
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69886592..69890837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69995766..70000011)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene gamma-aminobutyric acid receptor associated protein Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 2410141M05Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PHD finger protein 23
Names
PHD zinc finger containing protein JUNE1
novel PHD-finger protein JUNE1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291125.1NP_001278054.1  PHD finger protein 23 isoform b

    See identical proteins and their annotated locations for NP_001278054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK031159, AL596185, AY099327, BY632579, CA750740
    Consensus CDS
    CCDS70223.1
    UniProtKB/Swiss-Prot
    Q8BSN5
    Related
    ENSMUSP00000099064.3, ENSMUST00000101526.9
    Conserved Domains (1) summary
    cd15631
    Location:272315
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  2. NM_001291126.1NP_001278055.1  PHD finger protein 23 isoform c

    See identical proteins and their annotated locations for NP_001278055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK029376, BY262829, BY632579
    Consensus CDS
    CCDS78976.1
    UniProtKB/Swiss-Prot
    Q8BSN5
    Related
    ENSMUSP00000121780.2, ENSMUST00000153684.8
    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  3. NM_001291127.1NP_001278056.1  PHD finger protein 23 isoform c

    See identical proteins and their annotated locations for NP_001278056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK029376, AL596185, BM947867, BY632579
    Consensus CDS
    CCDS78976.1
    UniProtKB/Swiss-Prot
    Q8BSN5
    Related
    ENSMUSP00000120665.2, ENSMUST00000135814.2
    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  4. NM_030064.4NP_084340.2  PHD finger protein 23 isoform a

    See identical proteins and their annotated locations for NP_084340.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK031159, AL596185, AY099326, BY632579, CA750740
    Consensus CDS
    CCDS24929.1
    UniProtKB/Swiss-Prot
    Q8BSN5, Q9CWC8
    Related
    ENSMUSP00000018716.4, ENSMUST00000018716.10
    Conserved Domains (1) summary
    cd15631
    Location:339382
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69886592..69890837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534501.2XP_006534564.1  PHD finger protein 23 isoform X1

    See identical proteins and their annotated locations for XP_006534564.1

    Conserved Domains (1) summary
    cd15631
    Location:369412
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  2. XM_006534502.4XP_006534565.3  PHD finger protein 23 isoform X2

    Conserved Domains (1) summary
    cd15631
    Location:302345
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  3. XM_030246428.2XP_030102288.1  PHD finger protein 23 isoform X3

    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  4. XM_036157091.1XP_036012984.1  PHD finger protein 23 isoform X3

    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  5. XM_030246427.2XP_030102287.1  PHD finger protein 23 isoform X3

    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)
  6. XM_030246429.1XP_030102289.1  PHD finger protein 23 isoform X3

    Conserved Domains (1) summary
    cd15631
    Location:209252
    PHD_PHF23; PHD finger found in PHD finger protein 23 (PHF23)