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MLPH melanophilin [ Felis catus (domestic cat) ]

Gene ID: 780791, updated on 10-Feb-2026
Official Symbol
MLPH
Official Full Name
melanophilin
Primary source
VGNC:VGNC:63526
See related
Ensembl:ENSFCTG00005008966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
SlaC2-a
Orthologs
all
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Try the new Transcripts and proteins table
See MLPH in Genome Data Viewer
Location:
chromosome: C1
Exon count:
16
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (218193106..218236641)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (219392502..219434400)

Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene collagen type VI alpha 3 chain Neighboring gene uncharacterized LOC123379322 Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat. Ishida Y, et al. Genomics, 2006 Dec. PMID 16860533
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables myosin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
melanophilin
Names
exophilin-3
slp homolog lacking C2 domains a
synaptotagmin-like protein 2a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079655.1 → NP_001073123.1  melanophilin

    See identical proteins and their annotated locations for NP_001073123.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ469741
    UniProtKB/Swiss-Prot
    A0A2I2U8R1, A0SJ36, A0SJ37, M3WHG5
    Related
    ENSFCTP00005016377.1, ENSFCTT00005025113.1
    Conserved Domains (2) summary
    pfam02318
    Location:8 → 125
    FYVE_2; FYVE-type zinc finger
    pfam04698
    Location:426 → 556
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    218193106..218236641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023257818.2 → XP_023113586.2  melanophilin isoform X1

    UniProtKB/Swiss-Prot
    A0A2I2U8R1, A0SJ36, A0SJ37, M3WHG5
    UniProtKB/TrEMBL
    A0ABI7X1N3
    Related
    ENSFCTP00005016463.1, ENSFCTT00005025243.1
    Conserved Domains (1) summary
    cd15752
    Location:62 → 137
    FYVE_SlaC2-a; FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins

  2. XM_023257819.2 → XP_023113587.2  melanophilin isoform X2

    UniProtKB/Swiss-Prot
    A0A2I2U8R1, A0SJ36, A0SJ37, M3WHG5
    UniProtKB/TrEMBL
    A0ABI7X1T2
    Related
    ENSFCTP00005016481.1, ENSFCTT00005025276.1
    Conserved Domains (1) summary
    cd15752
    Location:62 → 137
    FYVE_SlaC2-a; FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M3WHG5.3 GenPept UniProtKB/Swiss-Prot:M3WHG5

Gene LinkOut

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Molecular Biology Databases
Research Materials