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TVP23A trans-golgi network vesicle protein 23 homolog A [ Homo sapiens (human) ]

Gene ID: 780776, updated on 13-Mar-2020

Summary

Official Symbol
TVP23Aprovided by HGNC
Official Full Name
trans-golgi network vesicle protein 23 homolog Aprovided by HGNC
Primary source
HGNC:HGNC:20398
See related
Ensembl:ENSG00000166676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM18A; YDR084C
Summary
This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in brain (RPKM 1.6), lymph node (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See TVP23A in Genome Data Viewer
Location:
16p13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (10758034..10818902, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10855221..10912651, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MT-ND4L pseudogene 24 Neighboring gene MT-ND4 pseudogene 34 Neighboring gene nucleotide binding protein 1 Neighboring gene uncharacterized LOC105371080 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene class II major histocompatibility complex transactivator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Golgi apparatus membrane protein TVP23 homolog A
Names
family with sequence similarity 18, member A
protein FAM18A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079512.4NP_001072980.1  Golgi apparatus membrane protein TVP23 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001072980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC074136, AK294418, AL833564, DA248626
    Consensus CDS
    CCDS45408.1
    UniProtKB/Swiss-Prot
    A6NH52
    Related
    ENSP00000299866.8, ENST00000299866.13
    Conserved Domains (1) summary
    pfam05832
    Location:30171
    DUF846; Eukaryotic protein of unknown function (DUF846)
  2. NM_001318873.2NP_001305802.1  Golgi apparatus membrane protein TVP23 homolog A isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC074136, AK124106, AL833564, DA248626
    Conserved Domains (1) summary
    pfam05832
    Location:1107
    DUF846; Eukaryotic protein of unknown function (DUF846)

RNA

  1. NR_134901.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region and has an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC074136, BC050569, BC171819, DA248626
  2. NR_134902.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC074136, BC050569, BC146886, DA248626
  3. NR_134903.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal exon, contains a alternate internal exon and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC074136, BC050569, BC171816, DA248626
    Related
    ENST00000572980.5
  4. NR_134904.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an internal exon, contains an additional alternate internal exon and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC074136, BC050569, BC171807, BC171817, DA248626
  5. NR_134905.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an internal exon and uses an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC074136, BC050569, BC171816, DA248626
  6. NR_134906.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and contains an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC074136, BC050569, BC171807, DA248626

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    10758034..10818902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720944.3XP_006721007.1  Golgi apparatus membrane protein TVP23 homolog A isoform X1

    See identical proteins and their annotated locations for XP_006721007.1

    UniProtKB/Swiss-Prot
    A6NH52
    Related
    ENSP00000460567.1, ENST00000575135.5
    Conserved Domains (1) summary
    pfam05832
    Location:30171
    DUF846; Eukaryotic protein of unknown function (DUF846)
  2. XM_017023649.2XP_016879138.1  Golgi apparatus membrane protein TVP23 homolog A isoform X1

    UniProtKB/Swiss-Prot
    A6NH52
    Conserved Domains (1) summary
    pfam05832
    Location:30171
    DUF846; Eukaryotic protein of unknown function (DUF846)
  3. XM_017023650.2XP_016879139.1  Golgi apparatus membrane protein TVP23 homolog A isoform X2

    Conserved Domains (1) summary
    pfam05832
    Location:1107
    DUF846; Eukaryotic protein of unknown function (DUF846)
  4. XM_017023651.2XP_016879140.1  Golgi apparatus membrane protein TVP23 homolog A isoform X2

    Related
    ENSP00000460822.1, ENST00000572428.5
    Conserved Domains (1) summary
    pfam05832
    Location:1107
    DUF846; Eukaryotic protein of unknown function (DUF846)
  5. XM_011522654.3XP_011520956.1  Golgi apparatus membrane protein TVP23 homolog A isoform X1

    See identical proteins and their annotated locations for XP_011520956.1

    UniProtKB/Swiss-Prot
    A6NH52
    Conserved Domains (1) summary
    pfam05832
    Location:30171
    DUF846; Eukaryotic protein of unknown function (DUF846)

RNA

  1. XR_001751978.1 RNA Sequence

  2. XR_001751979.1 RNA Sequence

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