U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpt1c carnitine palmitoyltransferase 1c [ Mus musculus (house mouse) ]

Gene ID: 78070, updated on 14-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Cpt1cprovided by MGI
Official Full Name
carnitine palmitoyltransferase 1cprovided by MGI
Primary source
MGI:MGI:2446526
See related
Ensembl:ENSMUSG00000007783 AllianceGenome:MGI:2446526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPT IC; CPT1-B; CPTI-B; CPT I-C; 6530437J22Rik; 9630004I06Rik
Summary
Predicted to enable carnitine O-palmitoyltransferase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in several cellular components, including dendrite; endoplasmic reticulum; and postsynapse. Is integral component of endoplasmic reticulum membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 73. Orthologous to human CPT1C (carnitine palmitoyltransferase 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 42.6), cortex adult (RPKM 27.5) and 17 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cpt1c in Genome Data Viewer
Location:
7; 7 B3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44607907..44624304, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44958483..44974880, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene testis-specific serine kinase substrate Neighboring gene protein arginine N-methyltransferase 1 Neighboring gene predicted gene 15545 Neighboring gene BCL2-like 12 (proline rich)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids. Fosch A, et al. Int J Mol Sci, 2023 Jan 15. PMID 36675212, Free PMC Article
  2. Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ(25-35). Ding Y, et al. Bioengineered, 2021 Dec. PMID 34424821, Free PMC Article
  3. CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity. Rodríguez-Rodríguez R, et al. Mol Metab, 2019 Jan. PMID 30448371, Free PMC Article
  4. Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement. Gratacòs-Batlle E, et al. Front Mol Neurosci, 2018. PMID 30135643, Free PMC Article
  5. Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice. Pozo M, et al. Endocrinology, 2017 Jul 1. PMID 28472467

See all (50) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids.
    Title: Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids.
  2. Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Abeta25-35.
    Title: Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ(25-35).
  3. Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
    Title: Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
  4. Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
    Title: Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
  5. CPT1C is necessary for the activation of BAT thermogenesis driven by leptin, HF diet exposure, and AMPK inhibition within the VMH.
    Title: CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.
  6. CPT1C in the mediobasal hypothalamus is necessary for proper hypothalamic sensing of a negative energy balance and fuel partitioning in liver and muscle.
    Title: Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice.
  7. data newly identify CPT1C as a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus
    Title: Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.
  8. Results indicate that altered ceramide metabolism in motor brain areas induced by Cpt1c deficiency causes progressive motor dysfunction from a young age
    Title: Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.
  9. The expression of CPT1C is induced by metabolic stress factors such as hypoxia and glucose deprivation in a p53 and AMP activated kinase-dependent manner.
    Title: Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model.
  10. ghrelin induces food intake through regulation of hypothalamic CPT1C and ceramide metabolism
    Title: Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC101932

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
carnitine O-palmitoyltransferase 1, brain isoform
Names
carnitine palmitoyltransferase 1, brain
NP_001239399.1
NP_001344599.1
NP_710146.1
XP_011249219.1
XP_011249220.1
XP_036009459.1
XP_036009460.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252470.1 → NP_001239399.1  carnitine O-palmitoyltransferase 1, brain isoform isoform 1

    See identical proteins and their annotated locations for NP_001239399.1

    Status: VALIDATED

    Source sequence(s)
    AK035790, BU758114, CN842042
    Consensus CDS
    CCDS21221.1
    UniProtKB/Swiss-Prot
    Q8BGD5, Q8C071
    Related
    ENSMUSP00000148815.2, ENSMUST00000212836.2
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 756
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 46
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  2. NM_001357670.1 → NP_001344599.1  carnitine O-palmitoyltransferase 1, brain isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155806
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 754
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 46
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. NM_153679.2 → NP_710146.1  carnitine O-palmitoyltransferase 1, brain isoform isoform 1

    See identical proteins and their annotated locations for NP_710146.1

    Status: VALIDATED

    Source sequence(s)
    AK035790, BU758114, CN842042
    Consensus CDS
    CCDS21221.1
    UniProtKB/Swiss-Prot
    Q8BGD5, Q8C071
    Related
    ENSMUSP00000069539.8, ENSMUST00000063761.8
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 756
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 46
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44607907..44624304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153566.1 → XP_036009459.1  carnitine O-palmitoyltransferase 1, brain isoform isoform X3

    Conserved Domains (1) summary
    pfam00755
    Location:2 → 369
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  2. XM_036153567.1 → XP_036009460.1  carnitine O-palmitoyltransferase 1, brain isoform isoform X3

    Conserved Domains (1) summary
    pfam00755
    Location:2 → 369
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  3. XM_011250918.2 → XP_011249220.1  carnitine O-palmitoyltransferase 1, brain isoform isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:1 → 502
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  4. XM_011250917.2 → XP_011249219.1  carnitine O-palmitoyltransferase 1, brain isoform isoform X1

    Conserved Domains (1) summary
    pfam00755
    Location:10 → 503
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RNA

  1. XR_882039.4 RNA Sequence

  2. XR_882038.3 RNA Sequence

  3. XR_882037.3 RNA Sequence

  4. XR_001778010.2 RNA Sequence

  5. XR_001778016.2 RNA Sequence

  6. XR_004934219.1 RNA Sequence

  7. XR_001778014.2 RNA Sequence

  8. XR_001778015.2 RNA Sequence

  9. XR_003946599.2 RNA Sequence

  10. XR_004934218.1 RNA Sequence

  11. XR_001778011.2 RNA Sequence

  12. XR_001778012.2 RNA Sequence

  13. XR_001778013.2 RNA Sequence

  14. XR_003946598.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGD5.1 GenPept UniProtKB/Swiss-Prot:Q8BGD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous