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Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) [ Mus musculus (house mouse) ]

Gene ID: 78038, updated on 30-Apr-2024

Summary

Official Symbol
Mccc2provided by MGI
Official Full Name
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)provided by MGI
Primary source
MGI:MGI:1925288
See related
Ensembl:ENSMUSG00000021646 AllianceGenome:MGI:1925288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCCB; 4930552N12Rik
Summary
Predicted to enable ATP binding activity and ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in coenzyme A metabolic process and leucine catabolic process. Located in mitochondrion. Is expressed in metanephros and spinal cord. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 24.4), liver adult (RPKM 15.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mccc2 in Genome Data Viewer
Location:
13 D1; 13 52.9 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100085040..100152147, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (99948532..100015639, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CART prepropeptide Neighboring gene predicted gene, 41039 Neighboring gene STARR-positive B cell enhancer ABC_E1885 Neighboring gene B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB Neighboring gene STARR-positive B cell enhancer ABC_E2419 Neighboring gene small EDRK-rich factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to methylcrotonoyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to methylcrotonoyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in coenzyme A metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of 3-methylcrotonyl-CoA carboxylase complex, mitochondrial ISO
Inferred from Sequence Orthology
more info
 
part_of methylcrotonoyl-CoA carboxylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of methylcrotonoyl-CoA carboxylase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Names
3-methylcrotonyl-CoA carboxylase 2
3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit
3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
MCCase subunit beta
NP_084302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030026.2NP_084302.1  methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

    See identical proteins and their annotated locations for NP_084302.1

    Status: VALIDATED

    Source sequence(s)
    AK145564, BC058987, BY237319
    Consensus CDS
    CCDS36764.1
    UniProtKB/Swiss-Prot
    Q3ULD5, Q3UPS6
    UniProtKB/TrEMBL
    B2RUK5
    Related
    ENSMUSP00000022148.7, ENSMUST00000022148.7
    Conserved Domains (2) summary
    PLN02820
    Location:8563
    PLN02820; 3-methylcrotonyl-CoA carboxylase, beta chain
    cl23717
    Location:84255
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100085040..100152147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)