Format

Send to:

Choose Destination

PTP4A1 protein tyrosine phosphatase 4A1 [ Homo sapiens (human) ]

Gene ID: 7803, updated on 8-Jul-2021

Summary

Official Symbol
PTP4A1provided by HGNC
Official Full Name
protein tyrosine phosphatase 4A1provided by HGNC
Primary source
HGNC:HGNC:9634
See related
Ensembl:ENSG00000112245 Ensembl:ENSG00000285976 MIM:601585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
Summary
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
Expression
Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PTP4A1 in Genome Data Viewer
Location:
6q12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (63516440..63583588)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (64226345..64293493)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lengsin, lens protein with glutamine synthetase domain Neighboring gene HNF1 motif-containing MPRA enhancer 15 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 5 Neighboring gene ribosomal protein L7a pseudogene 34 Neighboring gene Sharpr-MPRA regulatory region 7882 Neighboring gene Sharpr-MPRA regulatory region 1413 Neighboring gene ribosomal protein L9 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779M0721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 1
Names
PVT1/PTP4A1 fusion
phosphatase of regenerating liver 1
protein tyrosine phosphatase type IVA protein 1
protein tyrosine phosphatase type IVA, member 1
protein-tyrosine phosphatase of regenerating liver 1
NP_001372183.1
NP_001372184.1
NP_001372185.1
NP_001372186.1
NP_001372187.1
NP_001372188.1
NP_001372189.1
NP_001372191.1
NP_001372192.1
NP_001372194.1
NP_001372195.1
NP_001372196.1
NP_001372197.1
NP_003454.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385254.1NP_001372183.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  2. NM_001385255.1NP_001372184.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  3. NM_001385256.1NP_001372185.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Related
    ENSP00000497588.1, ENST00000648894.1
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  4. NM_001385257.1NP_001372186.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  5. NM_001385258.1NP_001372187.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  6. NM_001385259.1NP_001372188.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Related
    ENSP00000500859.1, ENST00000673199.1
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  7. NM_001385260.1NP_001372189.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Related
    ENSP00000500952.1, ENST00000672924.1
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  8. NM_001385262.2NP_001372191.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  9. NM_001385263.2NP_001372192.1  protein tyrosine phosphatase type IVA 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cl28904
    Location:1151
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  10. NM_001385265.1NP_001372194.1  protein tyrosine phosphatase type IVA 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cl28904
    Location:1135
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  11. NM_001385266.1NP_001372195.1  protein tyrosine phosphatase type IVA 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cl28904
    Location:1135
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  12. NM_001385267.2NP_001372196.1  protein tyrosine phosphatase type IVA 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1
  13. NM_001385268.2NP_001372197.1  protein tyrosine phosphatase type IVA 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Conserved Domains (1) summary
    cl28904
    Location:1154
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  14. NM_003463.5NP_003454.1  protein tyrosine phosphatase type IVA 1 isoform 1

    See identical proteins and their annotated locations for NP_003454.1

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Consensus CDS
    CCDS4965.1
    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Related
    ENSP00000485687.1, ENST00000626021.3
    Conserved Domains (1) summary
    cd18537
    Location:1167
    PTP-IVa1; protein tyrosine phosphatase type IVA 1

RNA

  1. NR_169593.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL135905
    Related
    ENST00000370651.7
  2. NR_169594.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL135905
  3. NR_169595.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL135905
  4. NR_169596.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL135905

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    63516440..63583588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center