Format

Send to:

Choose Destination

PTP4A1 protein tyrosine phosphatase type IVA, member 1 [ Homo sapiens (human) ]

Gene ID: 7803, updated on 8-Oct-2018

Summary

Official Symbol
PTP4A1provided by HGNC
Official Full Name
protein tyrosine phosphatase type IVA, member 1provided by HGNC
Primary source
HGNC:HGNC:9634
See related
Ensembl:ENSG00000112245 MIM:601585; Vega:OTTHUMG00000014949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
Summary
This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
Expression
Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues See more
Orthologs

Genomic context

See PTP4A1 in Genome Data Viewer
Location:
6q12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (63528021..63583588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (64281917..64293493)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lengsin, lens protein with glutamine synthetase domain Neighboring gene HNF1 motif-containing MPRA enhancer 15 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 5 Neighboring gene ribosomal protein L7a pseudogene 34 Neighboring gene ribosomal protein L9 pseudogene 18 Neighboring gene PHD finger protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779M0721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 1
Names
PVT1/PTP4A1 fusion
phosphatase of regenerating liver 1
protein tyrosine phosphatase type IVA protein 1
protein-tyrosine phosphatase 4a1
protein-tyrosine phosphatase of regenerating liver 1
NP_003454.1
XP_011534413.1
XP_011534414.1
XP_016866759.1
XP_016866760.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003463.4NP_003454.1  protein tyrosine phosphatase type IVA 1

    See identical proteins and their annotated locations for NP_003454.1

    Status: REVIEWED

    Source sequence(s)
    AW136267, BC023975, BC045571, BF436021, BP264358, CA427371
    Consensus CDS
    CCDS4965.1
    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Related
    OTTHUMP00000016675, OTTHUMT00000041083
    Conserved Domains (1) summary
    cl21483
    Location:11160
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    63528021..63583588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011270.1XP_016866759.1  protein tyrosine phosphatase type IVA 1 isoform X1

    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Related
    ENSP00000497588.1, ENST00000648894.1
    Conserved Domains (1) summary
    cl21483
    Location:11160
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_017011271.1XP_016866760.1  protein tyrosine phosphatase type IVA 1 isoform X1

    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Related
    ENSP00000485687.1, ENST00000626021.2
    Conserved Domains (1) summary
    cl21483
    Location:11160
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_011536112.1XP_011534414.1  protein tyrosine phosphatase type IVA 1 isoform X1

    See identical proteins and their annotated locations for XP_011534414.1

    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Conserved Domains (1) summary
    cl21483
    Location:11160
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. XM_011536111.1XP_011534413.1  protein tyrosine phosphatase type IVA 1 isoform X1

    See identical proteins and their annotated locations for XP_011534413.1

    UniProtKB/Swiss-Prot
    Q93096
    UniProtKB/TrEMBL
    A0A024R8J2
    Conserved Domains (1) summary
    cl21483
    Location:11160
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Support Center