gclc glutamate-cysteine ligase, catalytic subunit [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: gclcprovided by Xenbase
Official Full Name: glutamate-cysteine ligase, catalytic subunitprovided by Xenbase
Primary source: Xenbase:XB-GENE-1002435
See related: Ensembl:ENSXETG00000016009 AllianceGenome:Xenbase:XB-GENE-1002435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable glutamate-cysteine ligase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	5	NC_030681.2 (96702141..96730780)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	5	NC_030681.1 (114262439..114291081, complement)

Chromosome 5 - NC_030681.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutamate-cysteine ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-cysteine ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of glutamate-cysteine ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutamate--cysteine ligase catalytic subunit

NP_001072803.1

EC 6.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079335.1 → NP_001072803.1 glutamate--cysteine ligase catalytic subunit

See identical proteins and their annotated locations for NP_001072803.1

Status: PROVISIONAL

Source sequence(s)

BC121418

UniProtKB/TrEMBL

A0A6I8RN68, F6SUY2, Q0V9R9

Related

ENSXETP00000034936.3, ENSXETT00000034936.5

Conserved Domains (2) summary

PRK00087
Location:22 → 70

PRK00087; bifunctional 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/30S ribosomal protein S1

pfam03074
Location:237 → 609

GCS; Glutamate-cysteine ligase