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gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 780185, updated on 8-Mar-2025

Summary

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Official Symbol
gneprovided by Xenbase
Official Full Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseprovided by Xenbase
Primary source
Xenbase:XB-GENE-1003644
See related
Ensembl:ENSXETG00000007164 AllianceGenome:Xenbase:XB-GENE-1003644
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to act upstream of or within UDP-N-acetylglucosamine metabolic process. Human ortholog(s) of this gene implicated in GNE myopathy; sialuria; and thrombocytopenia. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
human mouse all
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Genomic context

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See gne in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (110071918..110106253, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (97905722..97940141, complement)

Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate synthase Neighboring gene clathrin light chain A Neighboring gene complexin 1 Neighboring gene polycomb group ring finger 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC145505

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables N-acylmannosamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine 2-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
NP_001072728.1
XP_012821303.1
XP_012821304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079260.1 → NP_001072728.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

    See identical proteins and their annotated locations for NP_001072728.1

    Status: PROVISIONAL

    Source sequence(s)
    BC125700
    UniProtKB/TrEMBL
    A0A6I8SN30, A0JM15, F6VZA1
    Related
    ENSXETP00000015559.4, ENSXETT00000015559.4
    Conserved Domains (2) summary
    COG1940
    Location:409 → 720
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl39071
    Location:11 → 374
    WecB; UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    110071918..110106253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012965849.3 → XP_012821303.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

    UniProtKB/TrEMBL
    A0A6I8RBY7, A0A6I8SPW1
    Related
    ENSXETP00000078460.1, ENSXETT00000100366.2
    Conserved Domains (2) summary
    COG1940
    Location:451 → 762
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl39071
    Location:53 → 416
    WecB; UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]

  2. XM_012965850.2 → XP_012821304.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

    See identical proteins and their annotated locations for XP_012821304.1

    UniProtKB/TrEMBL
    A0A6I8SN30, A0JM15, F6VZA1
    Related
    ENSXETP00000075886.1, ENSXETT00000087093.2
    Conserved Domains (2) summary
    COG1940
    Location:409 → 720
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl39071
    Location:11 → 374
    WecB; UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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