Ascc3 activating signal cointegrator 1 complex subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ascc3provided by MGI
Official Full Name: activating signal cointegrator 1 complex subunit 3provided by MGI
Primary source: MGI:MGI:1925237
See related: Ensembl:ENSMUSG00000038774 AllianceGenome:MGI:1925237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RNAH; Helic1; ASC1p200; D630041L21; B630009I04Rik; D430001L07Rik
Summary: Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in several processes, including DNA dealkylation involved in DNA repair; DNA duplex unwinding; and cellular protein metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 4.7), liver E14 (RPKM 3.6) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10; 10 B3

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (50468756..50727300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (50592663..50851202)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D10Mit57 (e-PCR), detects polymorphism
- UniSTS:126238

MARC_21686-21687:1044297767:1 (e-PCR)
- UniSTS:268607

MARC_10283-10284:998926151:3 (e-PCR)
- UniSTS:267096

D10Mit147 (e-PCR), detects polymorphism
- UniSTS:126049

D10Wsu159e (e-PCR), detects polymorphism
- UniSTS:141525

Homology

Homologs of the Ascc3 gene: The Ascc3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 480 organisms have orthologs with human gene Ascc3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 3'-5' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA dealkylation involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA repair complex	ISO Inferred from Sequence Orthology more info
part_of activating signal cointegrator 1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: activating signal cointegrator 1 complex subunit 3

Names: helicase, ATP binding 1

NP_932124.2

EC 3.6.4.12

XP_030101248.1

EC 3.6.4.12

XP_030101249.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198007.2 → NP_932124.2 activating signal cointegrator 1 complex subunit 3

See identical proteins and their annotated locations for NP_932124.2

Status: VALIDATED

Source sequence(s)

AC137877, AC153529, AC159114

Consensus CDS

CCDS48555.1

UniProtKB/Swiss-Prot

E9PZJ8, Q8K292

Related

ENSMUSP00000036726.9, ENSMUST00000035606.10

Conserved Domains (5) summary

smart00490
Location:1615 → 1694

HELICc; helicase superfamily c-terminal domain

smart00611
Location:1810 → 2179

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

COG1204
Location:461 → 1240

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

pfam00270
Location:1329 → 1500

DEAD; DEAD/DEAH box helicase

pfam02889
Location:979 → 1287

Sec63; Sec63 Brl domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

50468756..50727300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245388.2 → XP_030101248.1 activating signal cointegrator 1 complex subunit 3 isoform X1

Conserved Domains (3) summary

COG1204
Location:363 → 1142

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd18022
Location:1229 → 1417

DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

pfam18149
Location:152 → 193

Helicase_PWI; N-terminal helicase PWI domain
XM_030245389.2 → XP_030101249.1 activating signal cointegrator 1 complex subunit 3 isoform X2

Conserved Domains (2) summary

COG1204
Location:125 → 904

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd18022
Location:991 → 1179

DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3