Format

Send to:

Choose Destination

LUZP1 leucine zipper protein 1 [ Homo sapiens (human) ]

Gene ID: 7798, updated on 7-Jun-2020

Summary

Official Symbol
LUZP1provided by HGNC
Official Full Name
leucine zipper protein 1provided by HGNC
Primary source
HGNC:HGNC:14985
See related
Ensembl:ENSG00000169641 MIM:601422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUZP
Summary
This gene encodes a protein that contains a leucine zipper motif. The exact function of the encoded protein is not known. In mice this gene affects neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in small intestine (RPKM 10.5), duodenum (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See LUZP1 in Genome Data Viewer
Location:
1p36.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23084023..23177808, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23410516..23504301, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene testis expressed 46 Neighboring gene lysine demethylase 1A Neighboring gene microRNA 3115 Neighboring gene RNA, U6 small nuclear 514, pseudogene Neighboring gene RNA, U6 small nuclear 135, pseudogene Neighboring gene 5-hydroxytryptamine receptor 1D Neighboring gene ribosomal protein L29 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35697, KIAA0601

Gene Ontology Provided by GOA

Process Evidence Code Pubs
artery development IEA
Inferred from Electronic Annotation
more info
 
neural fold bending IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142546.1NP_001136018.1  leucine zipper protein 1

    See identical proteins and their annotated locations for NP_001136018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK093016, AL031428, BP200621
    Consensus CDS
    CCDS30628.1
    UniProtKB/Swiss-Prot
    Q86V48
    Related
    ENSP00000393460.1, ENST00000418342.5
    Conserved Domains (2) summary
    TIGR04527
    Location:262369
    mycoplas_twoTM; two transmembrane protein
    pfam15619
    Location:104303
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  2. NM_033631.4NP_361013.3  leucine zipper protein 1

    See identical proteins and their annotated locations for NP_361013.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL031428, BC016175, BP200621
    Consensus CDS
    CCDS30628.1
    UniProtKB/Swiss-Prot
    Q86V48
    UniProtKB/TrEMBL
    Q05DE3
    Conserved Domains (2) summary
    TIGR04527
    Location:262369
    mycoplas_twoTM; two transmembrane protein
    pfam15619
    Location:104303
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23084023..23177808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542091.3XP_011540393.1  leucine zipper protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540393.1

    UniProtKB/Swiss-Prot
    Q86V48
    Related
    ENSP00000303758.4, ENST00000302291.8
    Conserved Domains (2) summary
    TIGR04527
    Location:262369
    mycoplas_twoTM; two transmembrane protein
    pfam15619
    Location:104303
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  2. XM_011542090.3XP_011540392.1  leucine zipper protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011540392.1

    UniProtKB/Swiss-Prot
    Q86V48
    Conserved Domains (2) summary
    TIGR04527
    Location:262369
    mycoplas_twoTM; two transmembrane protein
    pfam15619
    Location:104303
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
  3. XM_017002252.2XP_016857741.1  leucine zipper protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86V48
    Conserved Domains (2) summary
    TIGR04527
    Location:262369
    mycoplas_twoTM; two transmembrane protein
    pfam15619
    Location:104303
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
Support Center