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sarm1 sterile alpha and TIR motif containing 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 779619, updated on 4-Jan-2025

Summary

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Official Symbol
sarm1provided by Xenbase
Official Full Name
sterile alpha and TIR motif containing 1provided by Xenbase
Primary source
Xenbase:XB-GENE-6033913
See related
Ensembl:ENSXETG00000034329 AllianceGenome:Xenbase:XB-GENE-6033913
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
sarm; samd2
Summary
Predicted to enable NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and signaling adaptor activity. Predicted to act upstream of or within several processes, including NAD catabolic process; negative regulation of MyD88-independent toll-like receptor signaling pathway; and regulation of axon regeneration. Predicted to be located in cytoplasm. Predicted to be active in dendrite. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See sarm1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (34914211..34935414, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (27315685..27332549, complement)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 member 2 Neighboring gene solute carrier family 46 (folate transporter), member 1 Neighboring gene vitronectin Neighboring gene sebox homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within NAD catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to axon injury IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sterile alpha and TIR motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    34914211..34935414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031896676.1 → XP_031752536.1  sterile alpha and TIR motif-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1J7A9
    Conserved Domains (3) summary
    cd09501
    Location:387 → 455
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:456 → 525
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:540 → 680
    TIR; Toll - interleukin 1 - resistance

  2. XM_012957456.3 → XP_012812910.1  sterile alpha and TIR motif-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1J7A9
    Conserved Domains (3) summary
    cd09501
    Location:387 → 455
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:456 → 525
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:540 → 680
    TIR; Toll - interleukin 1 - resistance

  3. XM_002937143.5 → XP_002937189.2  sterile alpha and TIR motif-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A6I8Q0H2
    Related
    ENSXETP00000062330.3, ENSXETT00000060627.3
    Conserved Domains (3) summary
    cd09501
    Location:404 → 472
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:473 → 542
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:557 → 697
    TIR; Toll - interleukin 1 - resistance
Nucleotide Protein Strain
Heading Accession and Version

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