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MAP3K12 mitogen-activated protein kinase kinase kinase 12 [ Homo sapiens (human) ]

Gene ID: 7786, updated on 21-Dec-2019

Summary

Official Symbol
MAP3K12provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 12provided by HGNC
Primary source
HGNC:HGNC:6851
See related
Ensembl:ENSG00000139625 MIM:600447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK; MUK; ZPK; ZPKP1; MEKK12
Summary
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See MAP3K12 in Genome Data Viewer
Location:
12q13.13
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53479669..53501205, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53873456..53893444, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene proline rich 13 Neighboring gene poly(rC) binding protein 2 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene Sharpr-MPRA regulatory region 3466 Neighboring gene ATF7-NPFF readthrough Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene activating transcription factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JUN kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
activation of JNKK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
histone phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 12
Names
MAPK-upstream kinase
dual leucine zipper bearing kinase
dual leucine zipper kinase DLK
leucine zipper protein kinase
mixed lineage kinase
protein kinase MUK
NP_001180440.1
NP_006292.3
XP_005269195.1
XP_005269197.1
XP_006719651.1
XP_011537027.1
XP_016875445.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193511.2NP_001180440.1  mitogen-activated protein kinase kinase kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_001180440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC023509, AK094195, BC050050
    Consensus CDS
    CCDS55831.1
    UniProtKB/Swiss-Prot
    Q12852
    Related
    ENSP00000449038.1, ENST00000547488.6
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. NM_006301.4NP_006292.3  mitogen-activated protein kinase kinase kinase 12 isoform 2

    See identical proteins and their annotated locations for NP_006292.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC023509, AK094195, U07358
    Consensus CDS
    CCDS8860.1
    UniProtKB/Swiss-Prot
    Q12852
    UniProtKB/TrEMBL
    A0A024RAY5
    Related
    ENSP00000267079.2, ENST00000267079.6
    Conserved Domains (2) summary
    smart00219
    Location:132364
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:131367
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53479669..53501205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538725.3XP_011537027.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    See identical proteins and their annotated locations for XP_011537027.1

    UniProtKB/Swiss-Prot
    Q12852
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. XM_005269138.4XP_005269195.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    See identical proteins and their annotated locations for XP_005269195.1

    UniProtKB/Swiss-Prot
    Q12852
    Related
    ENSP00000448689.1, ENST00000547035.5
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  3. XM_017019956.2XP_016875445.1  mitogen-activated protein kinase kinase kinase 12 isoform X2

    UniProtKB/Swiss-Prot
    Q12852
    UniProtKB/TrEMBL
    A0A024RAY5
    Conserved Domains (2) summary
    smart00219
    Location:132364
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:131367
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  4. XM_006719588.4XP_006719651.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    See identical proteins and their annotated locations for XP_006719651.1

    UniProtKB/Swiss-Prot
    Q12852
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  5. XM_005269140.2XP_005269197.1  mitogen-activated protein kinase kinase kinase 12 isoform X3

    Related
    ENSP00000447889.1, ENST00000552365.1
    Conserved Domains (2) summary
    smart00219
    Location:165397
    TyrKc; Tyrosine kinase, catalytic domain
    cd14059
    Location:164400
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
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