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Msl2 MSL complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 77853, updated on 8-Dec-2022

Summary

Official Symbol
Msl2provided by MGI
Official Full Name
MSL complex subunit 2provided by MGI
Primary source
MGI:MGI:1925103
See related
Ensembl:ENSMUSG00000066415 AllianceGenome:MGI:1925103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msl2l1; Rnf184; E130103E02Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in histone H4-K16 acetylation and protein ubiquitination. Predicted to be part of MSL complex. Is expressed in embryo. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.4), spleen adult (RPKM 9.6) and 28 other tissues See more
Orthologs
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Genomic context

See Msl2 in Genome Data Viewer
Location:
9; 9 E4
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100956107..100981999)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101074054..101104800)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene predicted gene, 46140 Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H4-K16 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MSL complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MSL2
Names
E3 ubiquitin-protein transferase MSL2
MSL2-like 1
male-specific lethal 2 homolog
male-specific lethal 2-like 1
male-specific lethal-2 homolog 1
ring finger protein 184

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100451.2NP_001093921.1  E3 ubiquitin-protein ligase MSL2 isoform 1

    See identical proteins and their annotated locations for NP_001093921.1

    Status: VALIDATED

    Source sequence(s)
    AK035934, BC070432, BC100371, BE986573
    Consensus CDS
    CCDS85717.1
    UniProtKB/Swiss-Prot
    Q69ZF8, Q8CBI7
    Related
    ENSMUSP00000082270.4, ENSMUST00000085177.5
    Conserved Domains (2) summary
    cd13122
    Location:456505
    MSL2_CXC; DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
    pfam16685
    Location:42111
    zf-RING_10; zinc RING finger of MSL2
  2. NM_001379344.1NP_001366273.1  E3 ubiquitin-protein ligase MSL2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC242670, AC242673
    Conserved Domains (3) summary
    TIGR03551
    Location:170212
    F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
    pfam16682
    Location:381435
    MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
    cl17238
    Location:137
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    100956107..100981999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)