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SLC30A4 solute carrier family 30 member 4 [ Homo sapiens (human) ]

Gene ID: 7782, updated on 5-Nov-2017
Official Symbol
SLC30A4provided by HGNC
Official Full Name
solute carrier family 30 member 4provided by HGNC
Primary source
HGNC:HGNC:11015
See related
Ensembl:ENSG00000104154 MIM:602095; Vega:OTTHUMG00000131439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT4; znT-4
Summary
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
15q21.1; 15q21.1
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (45479613..45523685, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45774676..45815005, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987223 Neighboring gene uncharacterized LOC105376714 Neighboring gene RNA, U7 small nuclear 5 pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 46 Neighboring gene developmental pluripotency associated 5 pseudogene 2 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 6

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of solute carrier family 30 (zinc transporter), member 4 (SLC30A4) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Zinc homeostasis, organism-specific biosystem (from WikiPathways)
    Zinc homeostasis, organism-specific biosystemZinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell ac...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of sequestering of zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc II ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
zinc ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
zinc transporter 4
Names
solute carrier family 30 (zinc transporter), member 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321036.1NP_001307965.1  zinc transporter 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC025580, BM789500, HY026192
    Conserved Domains (2) summary
    COG1230
    Location:109180
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:123179
    Cation_efflux; Cation efflux family
  2. NM_013309.5NP_037441.2  zinc transporter 4 isoform 1

    See identical proteins and their annotated locations for NP_037441.2

    Status: VALIDATED

    Source sequence(s)
    AC025580, BC026089, BC042520
    Consensus CDS
    CCDS10125.1
    UniProtKB/Swiss-Prot
    O14863
    Related
    ENSP00000261867.3, OTTHUMP00000162136, ENST00000261867.4, OTTHUMT00000254236
    Conserved Domains (1) summary
    TIGR01297
    Location:123413
    CDF; cation diffusion facilitator family transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

    Range
    45479613..45523685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521997.2XP_011520299.1  zinc transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_011520299.1

    UniProtKB/Swiss-Prot
    O14863
    Conserved Domains (1) summary
    TIGR01297
    Location:123413
    CDF; cation diffusion facilitator family transporter
  2. XM_017022560.1XP_016878049.1  zinc transporter 4 isoform X1

    UniProtKB/Swiss-Prot
    O14863
    Conserved Domains (1) summary
    TIGR01297
    Location:123413
    CDF; cation diffusion facilitator family transporter
  3. XM_017022562.1XP_016878051.1  zinc transporter 4 isoform X3

    Conserved Domains (2) summary
    COG1230
    Location:109180
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:123179
    Cation_efflux; Cation efflux family
  4. XM_017022561.1XP_016878050.1  zinc transporter 4 isoform X2

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    45890034..45933215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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