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SLC30A1 solute carrier family 30 member 1 [ Homo sapiens (human) ]

Gene ID: 7779, updated on 24-Nov-2020

Summary

Official Symbol
SLC30A1provided by HGNC
Official Full Name
solute carrier family 30 member 1provided by HGNC
Primary source
HGNC:HGNC:11012
See related
Ensembl:ENSG00000170385 MIM:609521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNT1; ZRC1
Expression
Ubiquitous expression in liver (RPKM 22.8), duodenum (RPKM 15.1) and 25 other tissues See more
Orthologs

Genomic context

See SLC30A1 in Genome Data Viewer
Location:
1q32.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (211571568..211579161, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211748381..211752099, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene retinal degeneration 3, GUCY2D regulator Neighboring gene uncharacterized LOC107985261 Neighboring gene uncharacterized LOC107985260 Neighboring gene uncharacterized LOC105372903 Neighboring gene Sharpr-MPRA regulatory region 10274

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cadmium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
detoxification of cadmium ion IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion import ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of zinc ion transmembrane import ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter 1
Names
solute carrier family 30 (zinc transporter), member 1
znT-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021194.3NP_067017.2  zinc transporter 1

    See identical proteins and their annotated locations for NP_067017.2

    Status: VALIDATED

    Source sequence(s)
    AA853540, AC105275, AI467909, AI621266, AW183618, BE744293, BF057194, CB990012, CF529684
    Consensus CDS
    CCDS1499.1
    UniProtKB/Swiss-Prot
    Q9Y6M5
    Related
    ENSP00000355968.4, ENST00000367001.5
    Conserved Domains (1) summary
    COG1230
    Location:6423
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    211571568..211579161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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