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Rnf170 ring finger protein 170 [ Mus musculus (house mouse) ]

Gene ID: 77733, updated on 26-Sep-2022

Summary

Official Symbol
Rnf170provided by MGI
Official Full Name
ring finger protein 170provided by MGI
Primary source
MGI:MGI:1924983
See related
Ensembl:ENSMUSG00000013878 AllianceGenome:MGI:1924983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720407G21Rik
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf170 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26609396..26633903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26119368..26143875)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 3 Neighboring gene RIKEN cDNA 1700047A11 gene Neighboring gene calcium binding protein 39 pseudogene Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene predicted gene, 31727

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118197

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF170
Names
RING-type E3 ubiquitin transferase RNF170
NP_001344221.1
NP_001344222.2
NP_001344223.2
NP_001344224.2
NP_084241.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357292.1NP_001344221.1  E3 ubiquitin-protein ligase RNF170 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093366, AI851211, AK042063, AK162554, BC114210
    Consensus CDS
    CCDS90380.1
    Related
    ENSMUSP00000118689.2, ENSMUST00000153528.8
    Conserved Domains (2) summary
    pfam06803
    Location:185218
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:68111
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
  2. NM_001357293.2NP_001344222.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    Conserved Domains (2) summary
    pfam06803
    Location:203236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
  3. NM_001357294.2NP_001344223.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    Conserved Domains (2) summary
    pfam06803
    Location:203236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
  4. NM_001357295.2NP_001344224.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    Conserved Domains (2) summary
    pfam06803
    Location:203236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
  5. NM_029965.4NP_084241.2  E3 ubiquitin-protein ligase RNF170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093366
    Consensus CDS
    CCDS22207.1
    Related
    ENSMUSP00000014022.9, ENSMUST00000014022.15
    Conserved Domains (2) summary
    pfam06803
    Location:203236
    DUF1232; Protein of unknown function (DUF1232)
    cd16553
    Location:86129
    RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins

RNA

  1. NR_151666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI851211, AK153658, AK162554, BC114210
  2. NR_151667.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093366

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26609396..26633903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)