U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

6030468B19Rik RIKEN cDNA 6030468B19 gene [ Mus musculus (house mouse) ]

Gene ID: 77727, updated on 5-Mar-2024

Summary

Official Symbol
6030468B19Rikprovided by MGI
Official Full Name
RIKEN cDNA 6030468B19 geneprovided by MGI
Primary source
MGI:MGI:1924977
See related
Ensembl:ENSMUSG00000025573 AllianceGenome:MGI:1924977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-40
Summary
Predicted to enable transmembrane signaling receptor activity. Involved in mature B cell differentiation involved in immune response and positive regulation of immunoglobulin production in mucosal tissue. Predicted to be located in extracellular space. Predicted to be integral component of plasma membrane. Orthologous to human C17orf99 (chromosome 17 open reading frame 99). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 83.6), liver E14 (RPKM 60.2) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See 6030468B19Rik in Genome Data Viewer
Location:
11 E2; 11 82.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117688460..117698134)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117797634..117807308)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 6 Neighboring gene STARR-positive B cell enhancer ABC_E1437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117642510-117642724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117643420-117643529 Neighboring gene STARR-positive B cell enhancer ABC_E5304 Neighboring gene STARR-positive B cell enhancer ABC_E9147 Neighboring gene predicted gene 11723 Neighboring gene transmembrane channel-like gene family 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117655547-117655805 Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene STARR-positive B cell enhancer ABC_E5306 Neighboring gene synaptogyrin 2 Neighboring gene STARR-positive B cell enhancer ABC_E11501 Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein IL-40
Names
interleukin-40
uncharacterized protein C17orf99 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029964.1NP_084240.1  protein IL-40 precursor

    See identical proteins and their annotated locations for NP_084240.1

    Status: VALIDATED

    Source sequence(s)
    AK020081, AL645856, BB843270
    Consensus CDS
    CCDS48992.1
    UniProtKB/Swiss-Prot
    B1ATC1, Q9CX63
    Related
    ENSMUSP00000101938.2, ENSMUST00000106331.2
    Conserved Domains (2) summary
    smart00410
    Location:139202
    IG_like; Immunoglobulin like
    pfam13927
    Location:136195
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117688460..117698134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534500.4XP_006534563.1  protein IL-40 isoform X3

    Conserved Domains (1) summary
    pfam17736
    Location:25116
    Ig_C17orf99; C17orf99 Ig domain
  2. XM_006534498.4XP_006534561.1  protein IL-40 isoform X1

    Conserved Domains (1) summary
    pfam17736
    Location:23117
    Ig_C17orf99; C17orf99 Ig domain
  3. XM_006534499.5XP_006534562.1  protein IL-40 isoform X2

    Conserved Domains (1) summary
    pfam17736
    Location:23117
    Ig_C17orf99; C17orf99 Ig domain