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ZNF112 zinc finger protein 112 [ Homo sapiens (human) ]

Gene ID: 7771, updated on 21-Dec-2019

Summary

Official Symbol
ZNF112provided by HGNC
Official Full Name
zinc finger protein 112provided by HGNC
Primary source
HGNC:HGNC:12892
See related
Ensembl:ENSG00000062370 MIM:603994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP112; ZNF228
Expression
Ubiquitous expression in thyroid (RPKM 2.5), prostate (RPKM 2.2) and 24 other tissues See more
Orthologs

Genomic context

See ZNF112 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44326553..44367215, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44830706..44860856, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene zinc finger protein 235 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 1 Neighboring gene zinc finger protein 285 Neighboring gene zinc finger protein 229

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF285

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 112
Names
zinc finger protein 112 (Y14)
zinc finger protein 112 homolog
zinc finger protein 228

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052954.1 RefSeqGene

    Range
    5001..45663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083335.2NP_001076804.1  zinc finger protein 112 isoform 1

    See identical proteins and their annotated locations for NP_001076804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3.
    Source sequence(s)
    AA449338, AC138473, DB288887
    Consensus CDS
    CCDS54276.1
    UniProtKB/Swiss-Prot
    Q9UJU3
    Related
    ENSP00000337081.3, ENST00000337401.8
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:384756
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:555575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:651675
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001348281.1NP_001335210.1  zinc finger protein 112 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC138473, AC245748
    Conserved Domains (5) summary
    smart00349
    Location:2585
    KRAB; krueppel associated box
    COG5048
    Location:401773
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:780873
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:572592
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:864888
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001348282.1NP_001335211.1  zinc finger protein 112 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 5, encodes isoform 2.
    Source sequence(s)
    AC138473, AC245748
    Consensus CDS
    CCDS12637.1
    UniProtKB/Swiss-Prot
    Q9UJU3
    Conserved Domains (5) summary
    smart00349
    Location:262
    KRAB; krueppel associated box
    COG5048
    Location:378750
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:757850
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:549569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:841865
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001348283.1NP_001335212.1  zinc finger protein 112 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2 and 4, encodes isoform 2.
    Source sequence(s)
    AC138473, AC245748
    Consensus CDS
    CCDS12637.1
    UniProtKB/Swiss-Prot
    Q9UJU3
    Conserved Domains (5) summary
    smart00349
    Location:262
    KRAB; krueppel associated box
    COG5048
    Location:378750
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:757850
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:549569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:841865
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001348284.2NP_001335213.1  zinc finger protein 112 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
    Source sequence(s)
    AC138473, AC245748
    Conserved Domains (4) summary
    COG5048
    Location:317689
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:696789
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:488508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:780804
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001348285.2NP_001335214.1  zinc finger protein 112 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 4.
    Source sequence(s)
    AC138473, AC245748
    Conserved Domains (4) summary
    COG5048
    Location:317689
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:696789
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:488508
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:780804
    zf-H2C2_2; Zinc-finger double domain
  7. NM_013380.4NP_037512.3  zinc finger protein 112 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, and 5 all encode the same isoform (2).
    Source sequence(s)
    AA449338, AC138473, BC117223
    Consensus CDS
    CCDS12637.1
    UniProtKB/TrEMBL
    Q0VG01
    Related
    ENSP00000346305.3, ENST00000354340.8
    Conserved Domains (5) summary
    smart00349
    Location:262
    KRAB; krueppel associated box
    COG5048
    Location:378750
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:757850
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:549569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:841865
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44326553..44367215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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