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ZNF226 zinc finger protein 226 [ Homo sapiens (human) ]

Gene ID: 7769, updated on 1-Jun-2020

Summary

Official Symbol
ZNF226provided by HGNC
Official Full Name
zinc finger protein 226provided by HGNC
Primary source
HGNC:HGNC:13019
See related
Ensembl:ENSG00000167380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 5.1), thyroid (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF226 in Genome Data Viewer
Location:
19q13.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44165062..44198261)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44669215..44682534)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100379224 Neighboring gene zinc finger protein 225 Neighboring gene zinc finger protein 234 Neighboring gene zinc finger protein 227 Neighboring gene zinc finger protein 233

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 226
Names
Kruppel-associated box protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032372.1NP_001027544.1  zinc finger protein 226 isoform a

    See identical proteins and their annotated locations for NP_001027544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AF228418, BC024197, CD700800
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000393265.1, ENST00000454662.6
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001032373.1NP_001027545.1  zinc finger protein 226 isoform a

    See identical proteins and their annotated locations for NP_001027545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, CD700800, CF596130
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000336719.5, ENST00000337433.9
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001032374.1NP_001027546.1  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_001027546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AC138470, BI457780, BX091242, CF596130
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    Related
    ENSP00000407474.1, ENST00000413984.6
    Conserved Domains (2) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  4. NM_001146220.2NP_001139692.1  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_001139692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate 3' exon, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AK314724, BC017786, BX537487, DA178589, DR002748
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    B2RBM0
    Related
    ENSP00000467003.1, ENST00000588742.5
    Conserved Domains (2) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  5. NM_001319088.1NP_001306017.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA080156, DB015503, DR002748
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001319089.1NP_001306018.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA178589, DA435005, DR002748
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001319090.1NP_001306019.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA178589, DA558473, DR002748
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  8. NM_015919.3NP_057003.2  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_057003.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AC138470, BI457780, CD700800, CF596130
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    Related
    ENSP00000300823.5, ENST00000300823.10
    Conserved Domains (2) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  9. NM_016444.2NP_057528.2  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AF228418, BC024197, DB174587
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000465121.1, ENST00000590089.5
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44165062..44198261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723367.3XP_006723430.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_006723430.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006723368.3XP_006723431.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_006723431.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027263.1XP_016882752.1  zinc finger protein 226 isoform X2

    UniProtKB/TrEMBL
    Q9NR94
    Conserved Domains (4) summary
    COG5048
    Location:242657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:139185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:372397
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006723369.2XP_006723432.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_006723432.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017027264.1XP_016882753.1  zinc finger protein 226 isoform X2

    UniProtKB/TrEMBL
    Q9NR94
    Conserved Domains (4) summary
    COG5048
    Location:242657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:139185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:372397
    zf-H2C2_2; Zinc-finger double domain
  6. XM_005259227.2XP_005259284.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_005259284.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017027265.1XP_016882754.1  zinc finger protein 226 isoform X3

    UniProtKB/Swiss-Prot
    Q9NYT6
    Conserved Domains (2) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  8. XM_017027262.1XP_016882751.1  zinc finger protein 226 isoform X1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:489514
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_002958356.1 RNA Sequence

  2. XR_002958357.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001032375.1: Suppressed sequence

    Description
    NM_001032375.1: This RefSeq was permanently suppressed because it represents the same transcript variant as NM_001032374.1, although the latter has a longer 5' UTR.
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