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ZNF226 zinc finger protein 226 [ Homo sapiens (human) ]

Gene ID: 7769, updated on 4-Jul-2021

Summary

Official Symbol
ZNF226provided by HGNC
Official Full Name
zinc finger protein 226provided by HGNC
Primary source
HGNC:HGNC:13019
See related
Ensembl:ENSG00000167380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 5.1), thyroid (RPKM 5.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF226 in Genome Data Viewer
Location:
19q13.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44165070..44198261)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44669253..44681838)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene zinc finger protein 225 Neighboring gene zinc finger protein 234 Neighboring gene zinc finger protein 227 Neighboring gene zinc finger protein 233

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 226
Names
Kruppel-associated box protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032372.2NP_001027544.1  zinc finger protein 226 isoform a

    See identical proteins and their annotated locations for NP_001027544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AC138470, AF228418, BC024197, CD700800
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000393265.1, ENST00000454662.6
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  2. NM_001032373.2NP_001027545.1  zinc finger protein 226 isoform a

    See identical proteins and their annotated locations for NP_001027545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, CD700800, CF596130
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000336719.5, ENST00000337433.10
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  3. NM_001032374.2NP_001027546.1  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_001027546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AC138470, BI457780, BX091242, CF596130
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    Related
    ENSP00000407474.1, ENST00000413984.6
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  4. NM_001146220.3NP_001139692.1  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_001139692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate 3' exon, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AK314724, BC017786, BX537487, DA178589
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    B2RBM0
    Related
    ENSP00000467003.1, ENST00000588742.5
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  5. NM_001319088.2NP_001306017.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA080156, DB015503
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  6. NM_001319089.2NP_001306018.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA178589, DA435005
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  7. NM_001319090.2NP_001306019.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    BC024197, DA178589, DA558473
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  8. NM_001388168.1NP_001375097.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  9. NM_001388169.1NP_001375098.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  10. NM_001388170.1NP_001375099.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  11. NM_001388171.1NP_001375100.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  12. NM_001388172.1NP_001375101.1  zinc finger protein 226 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  13. NM_001388173.1NP_001375102.1  zinc finger protein 226 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  14. NM_001388174.1NP_001375103.1  zinc finger protein 226 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  15. NM_001388175.1NP_001375104.1  zinc finger protein 226 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  16. NM_001388176.1NP_001375105.1  zinc finger protein 226 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  17. NM_001388177.1NP_001375106.1  zinc finger protein 226 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC138470
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  18. NM_001388178.1NP_001375107.1  zinc finger protein 226 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC138470, DA614159, DB117314
    Conserved Domains (4) summary
    COG5048
    Location:323738
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329349
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:220266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:270321
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  19. NM_015919.4NP_057003.2  zinc finger protein 226 isoform b

    See identical proteins and their annotated locations for NP_057003.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region, as well as in the 5' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 4, and 6 all encode isoform b.
    Source sequence(s)
    AC138470, BI457780, CD700800, CF596130
    Consensus CDS
    CCDS46103.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    Related
    ENSP00000300823.5, ENST00000300823.10
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
  20. NM_016444.3NP_057528.2  zinc finger protein 226 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, 7, 8, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AC138470, AF228418, BC024197, DB174587
    Consensus CDS
    CCDS46102.1
    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Related
    ENSP00000465121.1, ENST00000590089.5
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44165070..44198261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723367.3XP_006723430.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_006723430.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  2. XM_006723368.3XP_006723431.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_006723431.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  3. XM_017027263.1XP_016882752.1  zinc finger protein 226 isoform X2

    UniProtKB/TrEMBL
    Q9NR94
    Conserved Domains (4) summary
    COG5048
    Location:242657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:139185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:372397
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027264.1XP_016882753.1  zinc finger protein 226 isoform X2

    UniProtKB/TrEMBL
    Q9NR94
    Conserved Domains (4) summary
    COG5048
    Location:242657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:139185
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:372397
    zf-H2C2_2; Zinc-finger double domain
  5. XM_005259227.2XP_005259284.1  zinc finger protein 226 isoform X1

    See identical proteins and their annotated locations for XP_005259284.1

    UniProtKB/Swiss-Prot
    Q9NYT6
    UniProtKB/TrEMBL
    A0A024R0P4
    Conserved Domains (5) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:359774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:256302
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd20908
    Location:306357
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  6. XM_017027265.1XP_016882754.1  zinc finger protein 226 isoform X3

    UniProtKB/Swiss-Prot
    Q9NYT6
    Conserved Domains (1) summary
    smart00349
    Location:867
    KRAB; krueppel associated box

RNA

  1. XR_002958356.1 RNA Sequence

  2. XR_002958357.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001032375.1: Suppressed sequence

    Description
    NM_001032375.1: This RefSeq was permanently suppressed because it represents the same transcript variant as NM_001032374.1, although the latter has a longer 5' UTR.
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