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Arhgef38 Rho guanine nucleotide exchange factor 38 [ Mus musculus (house mouse) ]

Gene ID: 77669, updated on 11-Apr-2024

Summary

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Official Symbol
Arhgef38provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 38provided by MGI
Primary source
MGI:MGI:1924919
See related
Ensembl:ENSMUSG00000040969 AllianceGenome:MGI:1924919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130221D24Rik; D630013G24Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Orthologous to human ARHGEF38 (Rho guanine nucleotide exchange factor 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 61.57 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132818039..132940710, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133112278..133234949, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene TIP41, TOR signalling pathway regulator-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6130 Neighboring gene STARR-positive B cell enhancer ABC_E9573 Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene integrator complex subunit 12 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2 Neighboring gene STARR-seq mESC enhancer starr_09025 Neighboring gene STARR-seq mESC enhancer starr_09033 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_09034 Neighboring gene STARR-positive B cell enhancer ABC_E6131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • MGC54810

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 38
Names
Rho guanine nucleotide exchange factor (GEF) 38
putative Rho guanine nucleotide exchange factor FLJ20184 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368752.1 → NP_001355681.1  rho guanine nucleotide exchange factor 38 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124593, AC124605, AEKQ02022826
    Consensus CDS
    CCDS89690.1
    UniProtKB/Swiss-Prot
    E2QRQ2, Q80VK6, Q9D274
    Related
    ENSMUSP00000114238.4, ENSMUST00000147041.10
    Conserved Domains (4) summary
    cd07589
    Location:336 → 510
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd12141
    Location:710 → 766
    SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
    pfam00621
    Location:98 → 283
    RhoGEF; RhoGEF domain
    cl17036
    Location:585 → 641
    SH3; Src Homology 3 domain superfamily

  2. NM_029953.1 → NP_084229.1  rho guanine nucleotide exchange factor 38 isoform 2

    See identical proteins and their annotated locations for NP_084229.1

    Status: VALIDATED

    Source sequence(s)
    BC049886
    Consensus CDS
    CCDS17849.1
    UniProtKB/Swiss-Prot
    Q80VK6
    Related
    ENSMUSP00000124280.3, ENSMUST00000161022.9
    Conserved Domains (1) summary
    cl02571
    Location:98 → 217
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    132818039..132940710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VK6.2 GenPept UniProtKB/Swiss-Prot:Q80VK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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